Sanapo Laura, Wien Michael, Whitehead Matthew T, Blask Anna, Gallagher Michael, DeBiasi Roberta L, Du Plessis Adre
a Division of Fetal and Transitional Medicine.
b Division of Radiology , Children's National Health System , Washington , DC , USA.
J Matern Fetal Neonatal Med. 2017 Aug;30(16):1887-1890. doi: 10.1080/14767058.2016.1228103. Epub 2016 Sep 9.
We report a case of fetal cerebellar hemorrhage and hypoplasia, identified by fetal MRI after intrauterine blood transfusion at 21 weeks' gestation for treatment of severe anemia due to congenital Parvovirus infection. Postnatal MRI confirmed atrophy of bilateral cerebellar hemispheres and inferior vermis. Cerebellar capillaries may be extremely susceptible to hemodynamic changes in the setting of intrauterine blood transfusion due to severe anemia. Although the correlation between fetal intracranial anomalies and Parvovirus infection remains unclear, in this population, a detailed evaluation of the brain parenchyma should be considered prior to and after intrauterine blood transfusion.
我们报告了一例胎儿小脑出血和发育不全的病例，该病例在妊娠21周时因先天性细小病毒感染导致严重贫血而进行宫内输血后，通过胎儿磁共振成像（MRI）得以确诊。产后MRI证实双侧小脑半球和小脑蚓部下份萎缩。由于严重贫血，宫内输血时小脑毛细血管可能极易受到血流动力学变化的影响。虽然胎儿颅内异常与细小病毒感染之间的相关性仍不明确，但对于这一人群，在宫内输血前后均应考虑对脑实质进行详细评估。
