Sen Volkan, Bozkurt Ozan, Demir Omer, Esen Ahmet Adil, Mungan Ugur, Aslan Guven, Kefi Aykut, Celebi Ilhan
Department of Urology, Dokuz Eylul University School of Medicine, 35330 Izmir, Turkey.
Scientifica (Cairo). 2016;2016:6792484. doi: 10.1155/2016/6792484. Epub 2016 Aug 2.
Background. There is not enough evidence about clinical behavior of bladder cancer in younger patients. Objective. We aimed to evaluate the clinical characteristics and prognosis of bladder urothelial carcinoma patients under the age of 40 years. Methods. Medical records of patients listed in our cancer database were retrospectively reviewed. A total of 40 patients who were initially diagnosed with bladder urothelial carcinoma at the age less than 40 years were included in the study. Patients' records were reviewed for recurrence and progression rates, demographic data, medical history, and treatment modalities. Results. Pathological results revealed 33 (82.5%) Ta low-grade, 6 (15%) T1 high-grade, and 1 (2.5%) T2 high-grade urothelial carcinomas. Recurrence was detected in 14/39 (35.9%) patients but progression was not observed in any patients. The mean age of recurrent patients was significantly higher than nonrecurrent patients (34.8 versus 28.5 years; p < 0.05). Besides, recurrence was detected in only 1 patient with the age under 30 years (6.2%) and 13 patients (54.1%) between 30 and 40 years old, respectively (p < 0.05). Conclusion. Bladder urothelial carcinoma diagnosed at young age tends to be a low pathologic stage, with relatively low rate of recurrence and progression.
背景。关于年轻患者膀胱癌的临床行为，目前尚无足够证据。目的。我们旨在评估40岁以下膀胱尿路上皮癌患者的临床特征和预后。方法。对我们癌症数据库中列出的患者的病历进行回顾性审查。本研究共纳入40例最初诊断为年龄小于40岁的膀胱尿路上皮癌患者。审查患者的复发率、进展率、人口统计学数据、病史和治疗方式。结果。病理结果显示33例（82.5%）为Ta低级别、6例（15%）为T1高级别、1例（2.5%）为T2高级别尿路上皮癌。14/39例（35.9%）患者检测到复发，但未观察到任何患者出现进展。复发患者的平均年龄显著高于未复发患者（34.8岁对28.5岁；p<0.05）。此外，年龄在30岁以下的患者中仅1例（6.2%）检测到复发，30至40岁之间的患者中有13例（54.1%）检测到复发（p<0.05）。结论。年轻时诊断出的膀胱尿路上皮癌往往病理分期较低，复发和进展率相对较低。
