环状 RNA 早期史： splicing 的产物
Early history of circular RNAs, children of splicing.
机构信息
a Department of Chemistry , Illinois College , Jacksonville , Illinois , USA.
b Department of Biochemistry and Molecular Biology , University of Texas Medical Branch , Galveston , Texas , USA.
出版信息
RNA Biol. 2017 Aug 3;14(8):975-977. doi: 10.1080/15476286.2016.1227903. Epub 2016 Aug 26.
In this commentary we briefly summarize early work on circular RNAs derived from spliceosome mediated circularization. We highlight how this early work inspired work on the basic mechanisms of nuclear RNA splicing, the possible function of circular RNAs and the potential uses of circular RNAs as tools in biomedicine. Recent developments in the study of circular RNAs, summarized in this volume, have brought these questions back to the foreground.
在这篇评论中，我们简要总结了早期关于剪接体介导的环状化产生的环状 RNA 的工作。我们强调了早期工作如何启发了核 RNA 剪接的基本机制、环状 RNA 的可能功能以及环状 RNA 作为生物医学工具的潜在用途的研究。本卷中总结的环状 RNA 研究的最新进展使这些问题重新成为研究重点。
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