用于植物生长调节剂的二聚体-28-高油菜素甾醇的合成与初步评价

Synthesis and preliminary evaluation of dimeric-28-homobrassinosteroids for plant growth regulators.

作者信息

Phutdhawong Waya S, Ruensamran Wanwikar, Phutdhawong Weerachai

机构信息

Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom 73000, Thailand.

Bioproduct Science Program, Department of Science, Faculty of Liberal Arts and Science, Kasetsart University, Kampang Saen Campus, Nakhon Pathom 73140, Thailand.

出版信息

Steroids. 2016 Dec;116:38-44. doi: 10.1016/j.steroids.2016.08.016. Epub 2016 Aug 24.

DOI:10.1016/j.steroids.2016.08.016

PMID:27567032

Abstract

Preparation of synthetic analogues of 28-homobrassinosteroids is reported. Also, the addition of the 28-homocastasterone at the C6 carbonyl group via allyl Gringard reagent followed by olefin cross metathesis resulted in dimeric analogues. Rice lamina inclination assay showed that the replacement of the C6 carbonyl group by 6α-allyl and 6β hydroxyl groups led to a decrease in bioactivity, whereas the dimeric analogues showed a reduced but significant bioactivity when compared to the 28-homocastasterone.

摘要

报道了28-高油菜素甾醇类合成类似物的制备。此外，通过烯丙基格氏试剂在C6羰基处添加28-高卡甾酮，随后进行烯烃交叉复分解反应，得到了二聚体类似物。水稻叶片倾斜度测定表明，用6α-烯丙基和6β-羟基取代C6羰基会导致生物活性降低，而与28-高卡甾酮相比，二聚体类似物的生物活性虽有所降低，但仍很显著。