Determination of perazine serum levels by gas liquid chromatography under clinical routine conditions.
作者信息
Schley J, Riedel E, Müller-Oerlinghausen B
出版信息
J Clin Chem Clin Biochem. 1978 May;16(5):307-11. doi: 10.1515/cclm.1978.16.5.307.
PMID:27569
Abstract
A quantitative gas liquid chromatographic method for the determination of serum levels of perazine (10-[3'-(1''-methyl-4''-piperazinyl)-propyl]-phenothiazine) is described. Perazine is used as a neuroleptic drug. The main problem consists in optimizing the chromatographic system. A sensitivity of appr. 60--150 nmol/1 (20--50 microgram/1) serum is achieved. Examples of optimization, analyses with patient samples, and the reproducibility of the results are presented.
摘要
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