Del Vecchio Michele
Dipartimento di Oncologia Medica, Fondazione IRCCS Istituto Nazionale dei Tumori.
Recenti Prog Med. 2016 Aug;107(8):414-7. doi: 10.1701/2332.25062.
The treatment with immune checkpoint inhibitors has changed the entire natural history of advanced melanoma. In a recent study presented at the AACR Congress (New Orleans, April 16-20, 2016), immunotherapy with nivolumab was associated with overall survival rates of 41-42% at 3 years and with an overall survival rate of 35% at 4 and 5 years, suggesting a stable plateau over time and a significant proportion of advanced melanoma patients potentially cured.
免疫检查点抑制剂治疗改变了晚期黑色素瘤的整个自然病程。在2016年4月16日至20日于新奥尔良举行的美国癌症研究协会年会上公布的一项近期研究中,纳武单抗免疫疗法在3年时的总生存率为41%-42%,在4年和5年时的总生存率为35%,这表明随着时间推移生存率保持稳定,且相当比例的晚期黑色素瘤患者有可能被治愈。