Chiaruttini Giulia, Mele Silvia, Opzoomer James, Crescioli Silvia, Ilieva Kristina M, Lacy Katie E, Karagiannis Sophia N
St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, Faculty of Life Sciences and Medicine, King's College London, Guy's Hospital, London, UK.
NIHR Biomedical Research Centre at Guy's and St. Thomas's Hospitals and King's College London, King's College London, London, UK.
Oncoimmunology. 2017 Mar 3;6(4):e1294296. doi: 10.1080/2162402X.2017.1294296. eCollection 2017.
Evidence of tumor-resident mature B cell and antibody compartments and reports of associations with favorable prognosis in malignant melanoma suggest that humoral immunity could participate in antitumor defense. Likely striving to confer immunological protection while being subjected to tumor-promoting immune tolerance, B cells may engender multiple functions, including antigen processing and presentation, cytokine-mediated signaling, antibody class switching, expression and secretion. We review key evidence in support of multifaceted immunological mechanisms by which B cells may counter or contribute to malignant melanoma, and we discuss their potential translational implications. Dissecting the contributions of tumor-associated humoral responses can inform future treatment avenues.
肿瘤驻留成熟B细胞和抗体区室的证据以及恶性黑色素瘤中与良好预后相关的报道表明，体液免疫可能参与抗肿瘤防御。B细胞可能在受到促肿瘤免疫耐受的同时努力提供免疫保护，从而产生多种功能，包括抗原加工和呈递、细胞因子介导的信号传导、抗体类别转换、表达和分泌。我们回顾了支持B细胞可能对抗或促进恶性黑色素瘤的多方面免疫机制的关键证据，并讨论了它们潜在的转化意义。剖析肿瘤相关体液反应的作用可为未来的治疗途径提供信息。
