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Pharmacological eEF2K activation promotes cell death and inhibits cancer progression.
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2
Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase.
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3
Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling.
Mol Cell Biol. 2014 Nov 15;34(22):4088-103. doi: 10.1128/MCB.01035-14. Epub 2014 Sep 2.
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Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy.
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Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis.
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8
Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
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Repression of eEF2K transcription by NF-κB tunes translation elongation to inflammation and dsDNA-sensing.
Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22583-22590. doi: 10.1073/pnas.1909143116. Epub 2019 Oct 21.
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The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.
Cell. 2013 May 23;153(5):1064-79. doi: 10.1016/j.cell.2013.04.055.

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Characterizing the Human Fetal Perimeiotic 45,X Ovary at Single-Cell Resolution.
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mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia.
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RAIDS atlas of significant genetic and protein biomarkers in cervical cancer.
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Inhibition of protein translation under matrix-deprivation stress in breast cancer cells.
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Impact of silencing eEF2K expression on the malignant properties of chordoma.
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The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma.
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Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases.
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An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.
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Nelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activity.
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Differential Requirements for eIF4E Dose in Normal Development and Cancer.
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Regulation and roles of elongation factor 2 kinase.
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Controlling the unfolded protein response-mediated life and death decisions in cancer.
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Targeting the translation machinery in cancer.
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Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.
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Stress-mediated translational control in cancer cells.
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mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.
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