抗生素发现路线图。 - Suppr

Suppr

超能文献

Roadmap for antibiotic discovery.

作者信息

Shore Carolyn K, Coukell Allan

机构信息

The Pew Charitable Trusts, 901 E St. NW, Washington, DC 20004, USA.

出版信息

Nat Microbiol. 2016 May 26;1(6):16083. doi: 10.1038/nmicrobiol.2016.83.

DOI:10.1038/nmicrobiol.2016.83

PMID:27572847

Abstract

摘要

相似文献

Roadmap for antibiotic discovery.

Nat Microbiol. 2016 May 26;1(6):16083. doi: 10.1038/nmicrobiol.2016.83.

Antibiotic development - economic, regulatory and societal challenges.

Nat Rev Microbiol. 2020 May;18(5):267-274. doi: 10.1038/s41579-019-0293-3. Epub 2019 Nov 19.

The global preclinical antibacterial pipeline.

Nat Rev Microbiol. 2020 May;18(5):275-285. doi: 10.1038/s41579-019-0288-0. Epub 2019 Nov 19.

Antibiotic discovery in the twenty-first century: current trends and future perspectives.

J Antibiot (Tokyo). 2010 Aug;63(8):423-30. doi: 10.1038/ja.2010.62. Epub 2010 Jun 16.

[Open innovation center for drug discovery: a research-supporting network for drug discovery].

Nihon Yakurigaku Zasshi. 2013 Jun;141(6):327-32. doi: 10.1254/fpj.141.327.

The Global Antibiotic Research and Development Partnership (GARDP): a not-for-profit antibiotic development organisation.

Lancet Infect Dis. 2018 Dec;18(12):1304-1305. doi: 10.1016/S1473-3099(18)30661-3. Epub 2018 Nov 9.

New antibiotic development hailed as game changing.

Lancet Infect Dis. 2015 Mar;15(3):271-2. doi: 10.1016/S1473-3099(15)70072-1.

Antibiotic development pipeline slows to a trickle.

Lancet Infect Dis. 2017 Nov;17(11):1128-1129. doi: 10.1016/S1473-3099(17)30586-8.

Current strategies in lead discovery.

Curr Pharm Biotechnol. 2010 Nov;11(7):720. doi: 10.2174/138920110792927784.

The use of human embryonic stem cells in drug discovery. Counterpoint.

Clin Pharmacol Ther. 2011 May;89(5):641-3. doi: 10.1038/clpt.2011.19.

引用本文的文献

Amino Alcohols as Potential Antibiotic and Antifungal Leads.

Molecules. 2022 Mar 22;27(7):2050. doi: 10.3390/molecules27072050.

Modulators of protein-protein interactions as antimicrobial agents.

RSC Chem Biol. 2021 Feb 3;2(2):387-409. doi: 10.1039/d0cb00205d. eCollection 2021 Apr 1.

Identification of a New Antimicrobial, Desertomycin H, Utilizing a Modified Crowded Plate Technique.

Mar Drugs. 2021 Jul 27;19(8):424. doi: 10.3390/md19080424.

Mining for novel antibiotics.

Curr Opin Microbiol. 2021 Oct;63:66-69. doi: 10.1016/j.mib.2021.06.001. Epub 2021 Jul 2.

Physicochemical and Structural Parameters Contributing to the Antibacterial Activity and Efflux Susceptibility of Small-Molecule Inhibitors of Escherichia coli.

Antimicrob Agents Chemother. 2021 Mar 18;65(4). doi: 10.1128/AAC.01925-20.

Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics.

Antimicrob Agents Chemother. 2020 Dec 16;65(1). doi: 10.1128/AAC.01958-20.

Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in .

Comput Struct Biotechnol J. 2020 Jun 21;18:1548-1556. doi: 10.1016/j.csbj.2020.06.024. eCollection 2020.

Discovery of 4,6-bis(2-(()-benzylidene)hydrazinyl)pyrimidin-2-Amine with Antibiotic Activity.

ChemistryOpen. 2019 Jul 4;8(7):896-907. doi: 10.1002/open.201800241. eCollection 2019 Jul.

Fosfomycin Permeation through the Outer Membrane Porin OmpF.

Biophys J. 2019 Jan 22;116(2):258-269. doi: 10.1016/j.bpj.2018.12.002. Epub 2018 Dec 8.

A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA.

Chem Commun (Camb). 2018 Dec 18;55(1):95-98. doi: 10.1039/c8cc08485h.

本文引用的文献

Alternatives to antibiotics-a pipeline portfolio review.

Lancet Infect Dis. 2016 Feb;16(2):239-51. doi: 10.1016/S1473-3099(15)00466-1. Epub 2016 Jan 13.

ESKAPEing the labyrinth of antibacterial discovery.

Nat Rev Drug Discov. 2015 Aug;14(8):529-42. doi: 10.1038/nrd4572. Epub 2015 Jul 3.

Challenges of antibacterial discovery.

Clin Microbiol Rev. 2011 Jan;24(1):71-109. doi: 10.1128/CMR.00030-10.

Physicochemical properties of antibacterial compounds: implications for drug discovery.

J Med Chem. 2008 May 22;51(10):2871-8. doi: 10.1021/jm700967e. Epub 2008 Feb 9.

Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Nat Rev Drug Discov. 2007 Jan;6(1):29-40. doi: 10.1038/nrd2201. Epub 2006 Dec 8.

Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.

Clin Infect Dis. 1998 Jan;26(1):1-10; quiz 11-2. doi: 10.1086/516284.

Antistaphylococcal activity of a cyclic peptide, LY146032, and vancomycin.

Antimicrob Agents Chemother. 1986 Dec;30(6):938-9. doi: 10.1128/AAC.30.6.938.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

相似文献

Roadmap for antibiotic discovery.

Nat Microbiol. 2016 May 26;1(6):16083. doi: 10.1038/nmicrobiol.2016.83.

Antibiotic development - economic, regulatory and societal challenges.

Nat Rev Microbiol. 2020 May;18(5):267-274. doi: 10.1038/s41579-019-0293-3. Epub 2019 Nov 19.

The global preclinical antibacterial pipeline.

Nat Rev Microbiol. 2020 May;18(5):275-285. doi: 10.1038/s41579-019-0288-0. Epub 2019 Nov 19.

Antibiotic discovery in the twenty-first century: current trends and future perspectives.

J Antibiot (Tokyo). 2010 Aug;63(8):423-30. doi: 10.1038/ja.2010.62. Epub 2010 Jun 16.

[Open innovation center for drug discovery: a research-supporting network for drug discovery].

Nihon Yakurigaku Zasshi. 2013 Jun;141(6):327-32. doi: 10.1254/fpj.141.327.

The Global Antibiotic Research and Development Partnership (GARDP): a not-for-profit antibiotic development organisation.

Lancet Infect Dis. 2018 Dec;18(12):1304-1305. doi: 10.1016/S1473-3099(18)30661-3. Epub 2018 Nov 9.

New antibiotic development hailed as game changing.

Lancet Infect Dis. 2015 Mar;15(3):271-2. doi: 10.1016/S1473-3099(15)70072-1.

Antibiotic development pipeline slows to a trickle.

Lancet Infect Dis. 2017 Nov;17(11):1128-1129. doi: 10.1016/S1473-3099(17)30586-8.

Current strategies in lead discovery.

Curr Pharm Biotechnol. 2010 Nov;11(7):720. doi: 10.2174/138920110792927784.

The use of human embryonic stem cells in drug discovery. Counterpoint.

Clin Pharmacol Ther. 2011 May;89(5):641-3. doi: 10.1038/clpt.2011.19.

引用本文的文献

Amino Alcohols as Potential Antibiotic and Antifungal Leads.

Molecules. 2022 Mar 22;27(7):2050. doi: 10.3390/molecules27072050.

Modulators of protein-protein interactions as antimicrobial agents.

RSC Chem Biol. 2021 Feb 3;2(2):387-409. doi: 10.1039/d0cb00205d. eCollection 2021 Apr 1.

Identification of a New Antimicrobial, Desertomycin H, Utilizing a Modified Crowded Plate Technique.

Mar Drugs. 2021 Jul 27;19(8):424. doi: 10.3390/md19080424.

Mining for novel antibiotics.

Curr Opin Microbiol. 2021 Oct;63:66-69. doi: 10.1016/j.mib.2021.06.001. Epub 2021 Jul 2.

Physicochemical and Structural Parameters Contributing to the Antibacterial Activity and Efflux Susceptibility of Small-Molecule Inhibitors of Escherichia coli.

Antimicrob Agents Chemother. 2021 Mar 18;65(4). doi: 10.1128/AAC.01925-20.

Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics.

Antimicrob Agents Chemother. 2020 Dec 16;65(1). doi: 10.1128/AAC.01958-20.

Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in .

Comput Struct Biotechnol J. 2020 Jun 21;18:1548-1556. doi: 10.1016/j.csbj.2020.06.024. eCollection 2020.

Discovery of 4,6-bis(2-(()-benzylidene)hydrazinyl)pyrimidin-2-Amine with Antibiotic Activity.

ChemistryOpen. 2019 Jul 4;8(7):896-907. doi: 10.1002/open.201800241. eCollection 2019 Jul.

Fosfomycin Permeation through the Outer Membrane Porin OmpF.

Biophys J. 2019 Jan 22;116(2):258-269. doi: 10.1016/j.bpj.2018.12.002. Epub 2018 Dec 8.

A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA.

Chem Commun (Camb). 2018 Dec 18;55(1):95-98. doi: 10.1039/c8cc08485h.

本文引用的文献

Alternatives to antibiotics-a pipeline portfolio review.

Lancet Infect Dis. 2016 Feb;16(2):239-51. doi: 10.1016/S1473-3099(15)00466-1. Epub 2016 Jan 13.

ESKAPEing the labyrinth of antibacterial discovery.

Nat Rev Drug Discov. 2015 Aug;14(8):529-42. doi: 10.1038/nrd4572. Epub 2015 Jul 3.

Challenges of antibacterial discovery.

Clin Microbiol Rev. 2011 Jan;24(1):71-109. doi: 10.1128/CMR.00030-10.

Physicochemical properties of antibacterial compounds: implications for drug discovery.

J Med Chem. 2008 May 22;51(10):2871-8. doi: 10.1021/jm700967e. Epub 2008 Feb 9.

Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Nat Rev Drug Discov. 2007 Jan;6(1):29-40. doi: 10.1038/nrd2201. Epub 2006 Dec 8.

Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.

Clin Infect Dis. 1998 Jan;26(1):1-10; quiz 11-2. doi: 10.1086/516284.

Antistaphylococcal activity of a cyclic peptide, LY146032, and vancomycin.

Antimicrob Agents Chemother. 1986 Dec;30(6):938-9. doi: 10.1128/AAC.30.6.938.