Knapp C C, Washington J A
Antimicrob Agents Chemother. 1986 Dec;30(6):938-9. doi: 10.1128/AAC.30.6.938.
The inhibitory and bactericidal activities of a novel cyclic peptide antibiotic, LY146032, and vancomycin against oxacillin-susceptible and oxacillin-resistant staphylococci were compared. The MICs for 90% of strains were two- to fourfold higher for vancomycin than for LY146032. MBC/MIC ratios for all strains were less than or equal to 2. In killing rate studies with four strains of staphylococci, there was no detectable growth in the presence of 4X the MIC of either LY146032 or vancomycin after 24 h of incubation.
比较了新型环肽抗生素LY146032和万古霉素对苯唑西林敏感及苯唑西林耐药葡萄球菌的抑制和杀菌活性。90%菌株的万古霉素MIC比LY146032高2至4倍。所有菌株的MBC/MIC比值均小于或等于2。在对4株葡萄球菌的杀菌率研究中，孵育24小时后，在LY146032或万古霉素4倍MIC浓度下均未检测到细菌生长。
