Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka, 564-8680, Japan.
Top Curr Chem (Cham). 2016 Apr;374(2):11. doi: 10.1007/s41061-016-0012-8. Epub 2016 Feb 23.
The development of practical, efficient, and atom-economical methods for the formation of carbon-carbon bonds remains a topic of considerable interest in current synthetic organic chemistry. In this review, we have summarized selected topics from the recent literature with particular emphasis on C-alkylation processes involving hydrogen transfer using alcohols as alkylation reagents. This review includes selected highlights concerning recent progress towards the modification of catalytic systems for the α-alkylation of ketones, nitriles, and esters. Furthermore, we have devoted a significant portion of this review to the methylation of ketones, alcohols, and indoles using methanol. Lastly, we have also documented recent advances in β-alkylation methods involving the dimerization of alcohols (Guerbet reaction), as well as new developments in C-alkylation methods based on sp (3) C-H activation.
在当前的有机合成化学中，开发实用、高效、原子经济性的碳-碳键形成方法仍然是一个备受关注的话题。在这篇综述中，我们总结了近期文献中的一些选定主题，特别强调了涉及醇作为烷基化试剂的氢转移的 C-烷基化过程。本综述包括有关酮、腈和酯的α-烷基化的催化体系修饰的最新进展的精选亮点。此外，我们还将本综述的很大一部分用于使用甲醇对酮、醇和吲哚进行甲基化。最后，我们还记录了涉及醇的二聚化（Guerbet 反应）的β-烷基化方法的最新进展，以及基于 sp (3) C-H 活化的 C-烷基化方法的新发展。
