Brockhaus A C, Politt D, Lindlohr C, Saad S
Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG), Ressort Medizinische Biometrie, Köln, Deutschland.
Institut für Gesundheitsökonomie und Klinische Epidemiologie, Universität zu Köln, Köln, Deutschland.
Chirurg. 2016 Dec;87(12):1054-1062. doi: 10.1007/s00104-016-0263-5.
Recent developments in classical minimally invasive surgical procedures for colon resection aimed to minimize or even eliminate abdominal wall incisions, thus improving postoperative pain, patient recovery and aesthetics. A promising approach is the total laparoendoscopic colectomy (LEC) with transanal sample extraction. The aim of this study was the comparison of total LEC with conventional laparoscopic assisted surgery (LAS) and extraction incision.
We included 168 consecutive patients (LEC:112; LAS:56) with diverticular disease, rectal prolapse, benign or malignant tumors and analyzed retrospectively. The specimen was extracted transanally by LEC with a specially developed rectoscope; the LAS group required a minilaparotomy of 5 cm. The primary outcome was postoperative pain. Secondary outcomes included operating time, minor and major complication rates, number and length of extracted specimens, additional pain medication and duration of hospital stay.
The measured postoperative pain score values did not significantly differ between the two groups; however, consumption of postoperative pain medication was significantly higher in the LAS-group (p < 0.001). Due to the learning curve, the median operating time in the LEC group (120 min) was slightly longer than in the LAS group (100 min); however, it was reduced to 95 min in the last 50 operations. Patients in the LEC group were discharged from hospital one day earlier (median duration of hospital stay 6 days, p = 0.003). Compliaction rates were similar in both groups.
The technique of total LEC with transanal specimen extraction is designed to avoid a minilaparotomy and its associated morbidities. The LEC operation is feasible for a large group of patients, including overweight patients. The superiority of LEC in terms of reduced pain medication, shorter hospital stay and faster patient recovery, as shown in this study, needs to be confirmed by randomized controlled trials with longer follow-up periods.
经典的结肠切除微创手术的最新进展旨在尽量减少甚至消除腹壁切口,从而减轻术后疼痛、促进患者康复并改善美观效果。一种很有前景的方法是经肛门标本取出的全腹腔镜下结肠切除术(LEC)。本研究的目的是比较全LEC与传统腹腔镜辅助手术(LAS)及标本取出切口。
我们纳入了168例连续性患者(LEC组112例;LAS组56例),这些患者患有憩室病、直肠脱垂、良性或恶性肿瘤,并进行了回顾性分析。LEC组使用专门研制的直肠镜经肛门取出标本;LAS组需要做一个5厘米的小切口剖腹手术。主要结局指标是术后疼痛。次要结局指标包括手术时间、轻微和严重并发症发生率、取出标本的数量和长度、额外的止痛药物使用情况以及住院时间。
两组术后疼痛评分值的测量结果无显著差异;然而,LAS组术后止痛药物的消耗量显著更高(p < 0.001)。由于学习曲线的原因,LEC组的中位手术时间(120分钟)略长于LAS组(100分钟);但在最后50例手术中,该时间缩短至95分钟。LEC组患者出院时间提前一天(中位住院时间6天,p = 0.003)。两组的并发症发生率相似。
经肛门标本取出的全LEC技术旨在避免小切口剖腹手术及其相关的发病情况。LEC手术对包括超重患者在内的一大组患者是可行的。本研究显示,LEC在减少止痛药物使用、缩短住院时间和加快患者康复方面的优势,需要通过更长随访期的随机对照试验来证实。