Jaruratanasirikul Somchit, Tangtrakulwanich Boonsin, Rachatawiriyakul Pornruedee, Sriplung Hutcha, Limpitikul Wannee, Dissaneevate Pathikan, Khunnarakpong Nattasit, Tantichantakarun Pongsak
Department of Pediatrics, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Department of Orthopedic Surgery and Physical Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Congenit Anom (Kyoto). 2016 Sep;56(5):203-8. doi: 10.1111/cga.12154.
This is the first population-based study in Thailand on the prevalence of congenital limb defects (CLD). Data were obtained from recently established birth defects registries in three southern Thailand provinces during 2009-2013. Entries in the birth defects registries included live births, stillbirths after 24 weeks gestational age, and terminations of pregnancy following a prenatal diagnosis of fetal anomaly. The total of 186 393 births recorded included 424 CLD cases, giving an average prevalence of 2.27 per 1000 births (95% CI, 2.05-2.49). The most common CLD was talipes equinovarus (44.1%), followed by polydactyly (13.9%) and syndactyly (9.4%). The prevalence significantly increased with maternal age from 1.81 in mothers aged <30 years to 2.75 in mothers 30 to < 35 years, and to 2.94 in mothers ≥35 years (P = 0.004). Overall 9.4% of the CLDs were syndromic CLD, again with significantly greater percentages in pregnant women aged ≥35 years than the non-syndromic CLD (32.5% vs 17.5% respectively, P = 0.03). In conclusion, the overall prevalence of CLD in the 3 southern Thailand provinces examined was 2.27 per 1000 births, and syndromic CLD was significantly higher in pregnant women aged ≥35 years than younger pregnant women.
这是泰国第一项基于人群的先天性肢体缺陷（CLD）患病率研究。数据来自泰国南部三个省份最近建立的出生缺陷登记处，时间跨度为2009年至2013年。出生缺陷登记处的记录包括活产、孕龄24周后的死产以及产前诊断出胎儿异常后的终止妊娠情况。记录的186393例出生中，有424例CLD病例，平均患病率为每1000例出生2.27例（95%置信区间，2.05 - 2.49）。最常见的CLD是马蹄内翻足（44.1%），其次是多指畸形（13.9%）和并指畸形（9.4%）。患病率随母亲年龄显著增加，年龄小于30岁的母亲患病率为1.81，30至小于35岁的母亲为2.75，35岁及以上的母亲为2.94（P = 0.004）。总体而言，9.4%的CLD为综合征性CLD，同样，35岁及以上孕妇中综合征性CLD的比例显著高于非综合征性CLD（分别为32.5%和17.5%，P = 0.03）。总之，在所调查的泰国南部三个省份中，CLD的总体患病率为每1000例出生2.27例，35岁及以上孕妇的综合征性CLD显著高于年轻孕妇。
