血清胆碱酯酶2（CHE2）与γ-晶状体蛋白基因簇（CRYG）之间的连锁关系：定位于2号染色体。
Linkage between serum cholinesterase 2 (CHE2) and gamma-crystallin gene cluster (CRYG): assignment to chromosome 2.
作者信息
Eiberg H, Nielsen L S, Klausen J, Dahlén M, Kristensen M, Bisgaard M L, Møller N, Mohr J
机构信息
University Institute of Medical Genetics, Copenhagen, Denmark.
出版信息
Clin Genet. 1989 May;35(5):313-21. doi: 10.1111/j.1399-0004.1989.tb02951.x.
Serum cholinesterase 2 (CHE2) was examined in a Danish material of normal families that has been tested earlier for 70-78 classical marker systems and 25 RFLP systems. DNA for RFLP typing was provided by transforming 16-year-old frozen lymphocytes. The frequency of allele CHE2*C5+ in the Danish population was found to be 0.0430. The highest lod score was between CHE2 and the gamma-crystallin gene cluster (CRYG) (zeta = 4.21 at theta = 0.00 in females). The scores were from a single family with 15 children. CHE2 may, accordingly, be assigned to the location of CRYG: chromosome 2, bands q33-q35.
在一个丹麦正常家庭样本中检测了血清胆碱酯酶2（CHE2），该样本此前已针对70 - 78个经典标记系统和25个限制性片段长度多态性（RFLP）系统进行过检测。通过转化16岁的冷冻淋巴细胞来提供用于RFLP分型的DNA。丹麦人群中CHE2*C5 +等位基因的频率为0.0430。最高连锁值分数出现在CHE2与γ-晶状体蛋白基因簇（CRYG）之间（女性中，在θ = 0.00时，ζ = 4.21）。这些分数来自一个有15个孩子的家庭。因此，CHE2可能定位于CRYG所在位置：2号染色体，q33 - q35带。
Zotero 插件