Manganelli P, Salaffi F, Nervetti A, Raffaini N, Olivetti G
Rheumatic Disease Unit, University Hospital of Parma, Italy.
Clin Exp Rheumatol. 1989 May-Jun;7(3):273-6.
The relationship between structural changes of the minor salivary glands with age was evaluated by morphometric analysis in twenty patients with primary Sjögren's syndrome (prim. SS) (Group I) and in twenty sex and age-matched normal subjects (Group II). No statistically significant differences were found in the acinar tissue, intralobular ducts (ILD) and fibrous tissue between the two Groups. In contrast, there was a 5-fold increase in the volume fraction of inflammatory cells in Group 1. In both Groups the percentage of fibrous tissue and ILD increases and the percentage of acinar tissue decreases linearly with age. In Group I the increase in the volume percentage of fibrous tissue and the decrease in the volume fraction of the acinar tissue were not related to the volume percentage of inflammatory cells. These results demonstrate that in prim. SS the acinar atrophy is not related to the inflammatory process but is an age-dependent phenomenon.
通过形态计量分析，对20例原发性干燥综合征（prim. SS）患者（第一组）和20例性别及年龄匹配的正常受试者（第二组）的小唾液腺结构变化与年龄的关系进行了评估。两组之间在腺泡组织、小叶内导管（ILD）和纤维组织方面未发现统计学上的显著差异。相比之下，第一组中炎症细胞的体积分数增加了5倍。在两组中，纤维组织和ILD的百分比随年龄呈线性增加，而腺泡组织的百分比随年龄呈线性下降。在第一组中，纤维组织体积百分比的增加和腺泡组织体积分数的减少与炎症细胞的体积百分比无关。这些结果表明，在原发性干燥综合征中，腺泡萎缩与炎症过程无关，而是一种年龄依赖性现象。
