[慢性嗜中性粒细胞白血病合并多发性骨髓瘤：两例报告及文献复习]
[Chronic neutrophilic leukemia complicated with multiple myeloma: two cases report and literature review].
作者信息
Jiang B, Qi J Y, Li Q H, Xu Y, Sun M Y, Zheng W W, Chen F, Qiu L G
机构信息
Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2016 Aug 14;37(8):688-91. doi: 10.3760/cma.j.issn.0253-2727.2016.08.011.
OBJECTIVE
To explored the diagnosis and treatment of chronic neutrophilic leukemia (CNL) complicated with multiple myeloma (MM).
METHODS
The clinical features and molecular biological characteristics of 2 patients with CNL complicated with MM were summarized, and the diagnosis and treatment of the patients were retrospectively reviewed.
RESULTS
The diagnosis of CNL complicated with MM was established in 2 cases. Case 1 had CSF3R mutation (P733T), but CSF3R-exon 14 mutation and SETBP1 mutation were all negative. The neutrophil count returned to normal when MM was successfully treated in case 1. When the patient relapsed, neutrophil count increased again.
CONCLUSION
Coexistence of CNL and MM is rare. CSF3R is a very important molecular marker for CNL. To the best of our knowledge, it's the first time to report the coexistence of CNL and MM carried CSF3R mutation (P733T). Chemotherapy regimens for MM may be effective in the treatment of CNL complicated with MM.
目的
探讨慢性中性粒细胞白血病（CNL）合并多发性骨髓瘤（MM）的诊断与治疗。
方法
总结2例CNL合并MM患者的临床特征及分子生物学特征，并对患者的诊断与治疗进行回顾性分析。
结果
确诊2例CNL合并MM患者。病例1存在CSF3R突变（P733T），但CSF3R第14外显子突变和SETBP1突变均为阴性。病例1成功治疗MM后中性粒细胞计数恢复正常，患者复发时中性粒细胞计数再次升高。
结论
CNL与MM并存罕见。CSF3R是CNL非常重要的分子标志物。据我们所知，首次报道CNL与MM并存且携带CSF3R突变（P733T）。MM的化疗方案可能对治疗CNL合并MM有效。
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