Analysis of gene mutation characteristics in patients with chronic neutrophilic leukaemia.

This study aims to investigate the gene mutation characteristics of chronic neutrophilic leukaemia (CNL). This study retrospectively analyses the molecular biological characteristics, laboratory characteristics and clinical data of four patients with CNL that were admitted in the second Hospital of Shanxi Medical University from May 2014 to October 2016. On the basis of the molecular biological data of 22 patients with CNL and 4 patients with CNL, we further analysed the characteristics of CNL molecular mutation. Two out of the four patients with CNL were carriers of () mutation, among which two were carriers of mutation combined with mutation and mutation, and two were only carriers of mutation. According to the molecular biological data of 22 patients with CNL, 20 patients were positive for mutation. Two patients were positive for mutation. A total of 10 patients were positive for mutation which was correlated with the gene mutation ( = 0.03). A total of 13 patients were positive for mutation. No patients carried mutations in ASXL2 and MPL genes. mutation is the main tumorigenic mutation in CNL, in which mutation is the main mutation, and an extremely small number of CNL patients may be caused by mutation. and are the most common concomitant mutations in CNL with mutation, and and mutations may have a certain correlation.