Alayash A I, al-Quorain A
Duke University Marine Biomedical Center, Beaufort, N.C.
Clin Physiol Biochem. 1989;7(2):87-92.
Colorimetric determinations of glycosylated Hb were carried out in a sample (n = 97) of sickle cell anemia patients, and in an age- and sex-matched group of individuals (n = 45) heterozygous for sickle cell anemia, from the Eastern Province of Saudi Arabia. A statistically significant increase in the value of glycosylated Hb was found in sickle cell trait (HbAS) group, when compared with those of sickle cell anemia (HbSS) and normal (HbAA) groups. Since glycosylated Hb is considered a valid indicator of long-term blood glucose, and assuming normal red blood cell survival in HbAS carriers, the increased value of glycosylated Hb may suggest that there exists a higher incidence of undiagnosed diabetes mellitus in individuals with heterozygous inheritance for sickle cell hemoglobin than homozygous sickle cell patients and normal individuals. The mechanism underlying this observation remains to be defined.
对来自沙特阿拉伯东部省份的镰状细胞贫血患者样本（n = 97）以及年龄和性别匹配的镰状细胞贫血杂合子个体组（n = 45）进行了糖化血红蛋白的比色测定。与镰状细胞贫血（HbSS）组和正常（HbAA）组相比，镰状细胞性状（HbAS）组的糖化血红蛋白值有统计学意义的升高。由于糖化血红蛋白被认为是长期血糖的有效指标，并且假设HbAS携带者的红细胞存活正常，糖化血红蛋白值的升高可能表明，与纯合镰状细胞患者和正常个体相比，镰状细胞血红蛋白杂合遗传个体中未诊断出的糖尿病发病率更高。这一观察结果背后的机制仍有待确定。
