Nduka N, Owhochuku S M, Odike P
Department of Chemical Pathology, University of Port Harcourt Teaching Hospital, River State, Nigeria.
East Afr Med J. 1993 Oct;70(10):646-9.
The haematological indices and clinical manifestations of sickle cell disease (SCD) patients were investigated in a combined group of male and female Nigerians, and the results were matched against those from non-SCD individuals. Haemoglobin concentrations (Hb), red blood cell count (RBC) and packed cell volume (PCV) were significantly lower in the haemoglobin SS (HbSS) individuals than in the haemoglobin AS (HbAS) and haemoglobin AA (HbAA) individuals. White cell count (WBC) was of course higher in the HbSS patients as was the foetal haemoglobin (HbF) also. The clinical investigations show a 16% incidence of leg ulceration amongst the SCD patients and a 25% incidence of 'crisis state' requiring blood transfusion. Comparison of these findings with those obtained for Jamaicans and Saudi Arabian sickle cell patients show several differences indicating a milder disease in the Nigerian than the Jamaicans.
在一组尼日利亚男女混合的镰状细胞病（SCD）患者中，对其血液学指标和临床表现进行了研究，并将结果与非SCD个体的结果进行了对比。血红蛋白SS（HbSS）个体的血红蛋白浓度（Hb）、红细胞计数（RBC）和血细胞比容（PCV）显著低于血红蛋白AS（HbAS）和血红蛋白AA（HbAA）个体。当然，HbSS患者的白细胞计数（WBC）较高，胎儿血红蛋白（HbF）也较高。临床调查显示，SCD患者中腿部溃疡的发生率为16%，需要输血的“危象状态”发生率为25%。将这些结果与牙买加和沙特阿拉伯镰状细胞病患者的结果进行比较，发现存在一些差异，表明尼日利亚患者的病情比牙买加患者的病情较轻。
