Pozzessere G, Rizzo P A, Valle E, Mollica M A, Sanarelli L, Morano S, Pietravalle P, Di Mario U, Morocutti C
Istituto di Clinica delle Malattie Nervose e Mentali, University La Sapienza, Rome, Italy.
Diabetes Res. 1989 Jan;10(1):17-20.
Abnormal findings in visual (VEP), brainstem auditory (BAEP) and somatosensory (SEP) evoked potentials at early stages of Type 1 and Type 2 diabetes have recently been reported by our group. Our aim here was to perform a longitudinal study in diabetic patients at an early stage of the disease using a combined evoked potential analysis in order to evaluate the variation of neurological abnormalities over time. Nine Type 1 and 12 Type 2 diabetic patients were examined and a second recording was carried out after a mean interval of 15.7 months +/- 6.2 SD. VEP, BAEP and SEP were measured in all patients. At the first recording electrophysiological abnormalities, present in both Type 1 and Type 2 diabetes were more evident when a multimodal evaluation was used (44.4% and 66.7% respectively). The follow-up study showed that overall neurological abnormalities persisted in all those patients who had previously presented pathological values. Whereas the number of patients with pathological values remained unmodified, a tendency to progression, namely the number of nervous levels with electrophysiological abnormalities, was observed. Thus, our study confirms the appearance of anatomofunctional disorders in the central nervous system in short-term diabetes, shows the persistence of neurological impairment in such patients and reveals a progressive segmental involvement at different nervous levels.
我们团队最近报告了1型和2型糖尿病早期视觉诱发电位（VEP）、脑干听觉诱发电位（BAEP）和体感诱发电位（SEP）的异常发现。我们在此的目的是对疾病早期的糖尿病患者进行纵向研究，采用联合诱发电位分析，以评估神经学异常随时间的变化。对9例1型糖尿病患者和12例2型糖尿病患者进行了检查，并在平均间隔15.7个月±6.2标准差后进行了第二次记录。对所有患者测量了VEP、BAEP和SEP。在首次记录时，当采用多模式评估时，1型和2型糖尿病中存在的电生理异常更为明显（分别为44.4%和66.7%）。随访研究表明，所有先前出现病理值的患者中，总体神经学异常持续存在。虽然病理值患者的数量保持不变，但观察到一种进展趋势，即存在电生理异常的神经水平数量增加。因此，我们的研究证实了短期糖尿病患者中枢神经系统出现解剖功能障碍，表明此类患者神经功能损害持续存在，并揭示了不同神经水平的进行性节段性受累。
