Moreo G, Mariani E, Pizzamiglio G, Colucci G B
Divisione di Medicina Generale, Istituti Clinici di Perfezionamento, Milan, Italy.
Diabetologia. 1995 May;38(5):573-6. doi: 10.1007/BF00400726.
In order to assess the possible progression of neurological abnormalities over time and the value of visual evoked potential alterations in predicting stability and severity of diabetes-related optic pathway disease, a longitudinal study in non-insulin-dependent diabetic patients was performed. Neurological examination, visual evoked potentials with pattern reversal, motor and sensory nerve conduction velocities and metabolic control were studied in 18 non-insulin-dependent diabetic patients and in 35 normal control subjects at baseline and again after 4.6 +/- 0.8 years (range 4-6). At the first recording the peak P100 wave latencies were significantly delayed in the diabetic patients compared with the control subjects; signs of peripheral neuropathy were detected in five patients, clinical in three and in two there was only neurophysiological alteration without clinical signs. The second recording revealed no significant alterations of P100 latencies in patients compared with baseline, but the number with clinical signs and/or neurophysiological alterations with no clinical signs of peripheral neurological disease was increased to seven. In conclusion, we observed that visual evoked potential alterations were stable over time whereas peripheral neurological disease progressed and correlated positively with metabolic control.
为了评估神经功能异常随时间的可能进展情况，以及视觉诱发电位改变在预测糖尿病相关视神经通路疾病的稳定性和严重程度方面的价值，我们对非胰岛素依赖型糖尿病患者进行了一项纵向研究。在基线时以及4.6±0.8年（范围4 - 6年）后，对18例非胰岛素依赖型糖尿病患者和35例正常对照者进行了神经学检查、模式翻转视觉诱发电位、运动和感觉神经传导速度以及代谢控制情况的研究。在首次记录时，与对照者相比，糖尿病患者的P100波峰潜伏期明显延迟；5例患者检测到周围神经病变迹象，3例有临床症状，2例仅有神经生理学改变而无临床症状。第二次记录显示，与基线相比，患者的P100潜伏期无明显改变，但有临床症状和/或无周围神经疾病临床症状的神经生理学改变的患者数量增加到了7例。总之，我们观察到视觉诱发电位改变随时间稳定，而周围神经疾病进展，且与代谢控制呈正相关。
