Ninan Jacob, Naik Vinay, George Gemy Maria
Mayo Clinic Health Systems-Franciscan Healthcare, Department of Hospital Medicine, La Crosse, Wisconsin, USA.
Department of Pathology, Mayo Clinic Health Systems-Franciscan Healthcare, La Crosse, Wisconsin, USA.
BMJ Case Rep. 2016 Sep 1;2016:bcr2016215857. doi: 10.1136/bcr-2016-215857.
A 67-year-old woman with a history of lung adenocarcinoma presented with 3 weeks of redness, pain, swelling and skin changes in her right breast. Her vital signs and physical examination were within physiological limits except for the right breast. She had extensive red streaks radiating from the right nipple with peau d'orange appearance of her overlying skin. Her breast was tender on examination and did not have any associated cervical or axillary lymphadenopathy. Her mammography revealed thickening of the skin, increased parenchymal markings and shrinkage the breast. Multiple skin biopsies demonstrated moderately differentiated lung adenocarcinoma with lymphovascular invasion. The patient made an informed decision to undergo radiotherapy following discussion with her oncologist and breast surgeon. She succumbed to her illness 2 months after the diagnosis of metastasis to her breast.
一名67岁有肺腺癌病史的女性,右乳出现发红、疼痛、肿胀及皮肤改变3周。除右乳外,其生命体征和体格检查均在生理范围内。她右乳头有广泛的红色条纹,其上覆皮肤呈橘皮样外观。检查时其乳房压痛,未伴有任何颈部或腋窝淋巴结病。她的乳房X线摄影显示皮肤增厚、实质纹理增多及乳房萎缩。多次皮肤活检显示为中度分化的肺腺癌伴淋巴管浸润。经与肿瘤学家和乳腺外科医生讨论后,患者做出了接受放疗的明智决定。在诊断为乳腺癌转移2个月后,她因病去世。