DAT Conformation Does Not Predict the Ability of Atypical Dopamine Uptake Inhibitors to Substitute for Cocaine.
作者信息
Hiranita Takato
机构信息
Division of Neurotoxicology, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, USA.
出版信息
J Alcohol Drug Depend. 2016;4(4). doi: 10.4172/2329-6488.1000e132. Epub 2016 Aug 8.
Abstract
摘要
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Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists.亚型选择性σ受体拮抗剂对可卡因或σ受体激动剂自我给药的阻断作用。
J Pharmacol Exp Ther. 2016 Jul;358(1):109-24. doi: 10.1124/jpet.116.232728. Epub 2016 Apr 21.
3
2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations.2-取代的3β-芳基托烷可卡因类似物产生非典型效应而不诱导内向型多巴胺转运体构象。
J Pharmacol Exp Ther. 2016 Mar;356(3):624-34. doi: 10.1124/jpet.115.230722. Epub 2016 Jan 14.
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Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter.针对多巴胺转运体的非典型药物的行为学、生物学及化学视角
Drug Alcohol Depend. 2015 Feb 1;147:1-19. doi: 10.1016/j.drugalcdep.2014.12.005. Epub 2014 Dec 18.
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2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter.可卡因 2-异恶唑-3-基苯硫代烷衍生物：多巴胺转运体的分子和非典型系统效应。
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Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.双重抑制多巴胺转运体和 σ 受体可减少可卡因的自我给药。
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Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.西格玛受体激动剂：通过微透析评估受体结合及对中脑边缘多巴胺神经传递的影响
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