Piwowarska Jadwiga, Radziwoń-Zaleska Maria, Dmochowska Martyna, Szepietowska Ewa, Matsumoto Halina, Sygitowicz Grażyna, Pilc Andrzej, Łukaszkiewicz Jacek
Department of Biochemistry and Clinical Chemistry, Medical University, Warszawa, Poland.
Department of Psychiatry, Medical University, Warszawa, Poland.
Pharmacol Rep. 2016 Dec;68(6):1120-1125. doi: 10.1016/j.pharep.2016.06.016. Epub 2016 Jul 1.
The aim of the study is to evaluate the advisability of systematic monitoring of clozapine (CLO) concentration in serum during treatment of schizophrenia in Polish psychiatric patients.
The concentration of CLO and its metabolites: norclozapine (NCLO) and clozapine N-oxide (CLO-NO) in serum obtained from 107 patients suffering from schizophrenia was determined by high performance liquid chromatography (HPLC) method. There were two groups of patients. In the first group of patients (n=95) the concentration of drug and its metabolites was determined by one-time testing. Correlations were tested using the test statistics. In the second group of patients (n=12), 51 samples of serum were provided by the same patient in different time spans (from 6days to 14 months after the beginning of the treatment).
Concentrations of CLO and its metabolites in blood serum do not always show a linear dependence on the applied dose for individual patients.
The high volatility of CLO concentrations in blood serum of patients treated with identical doses of the drug confirmed the validity of the monitored therapy.
本研究的目的是评估在波兰精神病患者治疗精神分裂症期间，系统监测血清中氯氮平（CLO）浓度的 advisability。
采用高效液相色谱（HPLC）法测定 107 例精神分裂症患者血清中 CLO 及其代谢产物：去甲氯氮平（NCLO）和氯氮平 N - 氧化物（CLO - NO）的浓度。患者分为两组。第一组患者（n = 95）通过一次性检测确定药物及其代谢产物的浓度。使用检验统计量检验相关性。第二组患者（n = 12）在不同时间段（治疗开始后 6 天至 14 个月）由同一患者提供 51 份血清样本。
血清中 CLO 及其代谢产物的浓度对个体患者而言并不总是与所用剂量呈线性相关。
接受相同剂量药物治疗的患者血清中 CLO 浓度的高波动性证实了监测治疗的有效性。
