Tani E, Yamagata S, Maeda Y, Ito Y
J Neurosurg. 1978 Aug;49(2):239-48. doi: 10.3171/jns.1978.49.2.0239.
The cytochemical localization of adenylate cyclase and guanylate cyclase was studied in the arteries of the circle of Willis in dogs. The reaction products of both adenylate and guanylate cyclases were similarly distributed and selectively localized predominantly adjacent to sarcoplasmic reticulum and sparsely to mitochondria and outer nuclear membranes of vascular smooth muscles. The observations could suggest a close association of the intracellular localizations of both cyclases and the intracellular calcium storage sites, and ultimately contribute to our complete understanding of regulation of cerebral blood flow and vasospasm.
在犬脑底动脉环的动脉中研究了腺苷酸环化酶和鸟苷酸环化酶的细胞化学定位。腺苷酸环化酶和鸟苷酸环化酶的反应产物分布相似，且主要选择性地定位于肌浆网附近，而在血管平滑肌的线粒体和外核膜上分布较少。这些观察结果提示两种环化酶在细胞内的定位与细胞内钙储存位点密切相关，并最终有助于我们全面了解脑血流量的调节和血管痉挛。
