Voronin V M, Litvinov N N, Shamarin A A, Kazachkov V I, Zhurkov V S
Eksp Onkol. 1989;11(4):20-3.
The relationship between the tumour frequency and nitrosodimethylamine (NDMA) concentration in drinking water was studied in the experiments involving 495 (CBA x C57Bl/6)F1 hybrid and 600 noninbred mice of both sex. At the NDMA concentrations of 0.04, 0.2, 1.0, 5.0 mg/l the tumour frequency was as follows: 21.6/26.2, 35.5/27.3, 57.4/56.4, 90.5/72.9% (20.0/20.0% in control) in hybrid mice; and 15.4/39.6, 18.2/43.5, 62.2/61.0, 76.5/87.5% (15.0/30.0% in control) in noninbred mice, respectively. In the given experiments the minimal effective NDMA concentration was 1.0 mg/l, and the maximal effective one--0.2 mg/l both for the hybrids and noninbred animals. The results of the research may be used for calculation of the MPC for NDMA.
在涉及495只（CBA×C57Bl/6）F1杂种小鼠和600只非近交系雌雄小鼠的实验中，研究了饮用水中肿瘤发生率与亚硝基二甲胺（NDMA）浓度之间的关系。在NDMA浓度为0.04、0.2、1.0、5.0mg/L时，杂种小鼠的肿瘤发生率如下：21.6/26.2、35.5/27.3、57.4/56.4、90.5/72.9%（对照组为20.0/20.0%）；非近交系小鼠的肿瘤发生率分别为15.4/39.6、18.2/43.5、62.2/61.0、76.5/87.5%（对照组为15.0/
