Zeigler M, Sury V, Bach G
Department of Human Genetics, Hadassah University Hospital, Jerusalem, Israel.
Eur J Biochem. 1989 Aug 1;183(2):455-8. doi: 10.1111/j.1432-1033.1989.tb14949.x.
In this report we present evidence for the existence of a lysosomal ganglioside sialidase. The sialidase activity was solubilized by sonication and stimulated by cholate. The absence of ganglioside sialidase activity in sialidosis patients indicates that lysosomal sialidase is active towards gangliosides and glycoproteins. The plasma membranes were associated with two types of ganglioside sialidase activities, one was enhanced by cholate while the other was partially inhibited by this detergent.
在本报告中，我们提供了溶酶体神经节苷脂唾液酸酶存在的证据。唾液酸酶活性通过超声处理溶解，并受胆酸盐刺激。唾液酸沉积症患者缺乏神经节苷脂唾液酸酶活性，这表明溶酶体唾液酸酶对神经节苷脂和糖蛋白具有活性。质膜与两种类型的神经节苷脂唾液酸酶活性相关，一种受胆酸盐增强，而另一种则被这种去污剂部分抑制。
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