Caradu C, Battut A S, Gonthier C, Midy D, Ducasse E
Service de chirurgie vasculaire, université de Bordeaux, hôpital Pellegrin, place Amélie-Raba-Léon, 33000 Bordeaux, France.
Service de chirurgie vasculaire, université de Bordeaux, hôpital Pellegrin, place Amélie-Raba-Léon, 33000 Bordeaux, France.
J Mal Vasc. 2016 Dec;41(6):378-382. doi: 10.1016/j.jmv.2016.07.006. Epub 2016 Sep 2.
One third of patients with critical limb ischemia (CLI) has below the knee lesions and requires a restoration of direct blood flow into the foot. However, many of these patients are ineligible for open surgery. The primary goals thus become pain relief and limb salvage over patency. The angiosome concept helps determine the target artery to treat in priority. The endovascular approach has decreased morbidity and mortality rates compared to distal bypass surgery; while subintimal retrograde, trans-collateral and loop techniques push the limits of open surgery by reopening the plantar arch, thereby improving run-off. Early restenosis phenomena after angioplasty have been improved by the use of - limus drug eluting balloons and balloon expandable stents in case of flow limiting dissection or recoil with increased limb salvage rates. Moreover, drug-eluting stents have been proposed, and allow a reduction in reintervention and in-stent restenosis rates in short lesions; however, results on amputation rates or survival are limited. Vessel preparation is a key to overcoming some current limitations, including atherectomy, which increases technical success rates and reduces restenosis rates, especially in calcified lesions, chronic total occlusions and restenosis. These advanced techniques in distal endovascular revascularization have revolutionized limb salvage and support the interest of an endovascular first approach in CLI treatment.
三分之一的严重下肢缺血(CLI)患者存在膝下病变,需要恢复足部的直接血流。然而,这些患者中的许多人不适合进行开放手术。因此,主要目标变成了缓解疼痛和挽救肢体而非维持血管通畅。血管区域概念有助于确定优先治疗的目标动脉。与远端旁路手术相比,血管内治疗方法降低了发病率和死亡率;而内膜下逆行、经侧支和襻技术通过重新开通足底弓突破了开放手术的极限,从而改善了血流。血管成形术后的早期再狭窄现象通过使用西罗莫司药物洗脱球囊以及在出现血流受限的夹层或回缩时使用球囊扩张支架得到改善,肢体挽救率有所提高。此外,药物洗脱支架也已被提出,可降低短病变的再次干预率和支架内再狭窄率;然而,关于截肢率或生存率的结果有限。血管准备是克服当前一些局限性的关键,包括旋切术,它可提高技术成功率并降低再狭窄率,尤其是在钙化病变、慢性完全闭塞和再狭窄的情况下。这些远端血管内血运重建的先进技术彻底改变了肢体挽救的局面,并支持在CLI治疗中优先采用血管内治疗方法。