Munck Camille, Mordon Serge, Betrouni Nacim
Univ. Lille, Inserm, CHU Lille, U1189 - ONCO-THAI - Image Assisted Laser Therapy for Oncology, F-59000 Lille, France; Department of Pulmonary and Thoracic Oncology, Lille University Hospital, Lille, France.
Univ. Lille, Inserm, CHU Lille, U1189 - ONCO-THAI - Image Assisted Laser Therapy for Oncology, F-59000 Lille, France.
Photodiagnosis Photodyn Ther. 2016 Dec;16:23-26. doi: 10.1016/j.pdpdt.2016.08.010. Epub 2016 Sep 1.
Complete and homogeneous illumination of the pleural cavity is essential to the success of photodynamic therapy (PDT) for mesothelioma, but remains a challenge. Knowing the repartition and propagation of light around the light applicator could be the first step towards optimizing dosimetry. Here we propose a characterization method of the illumination profile of a specific light device.
The light wand, made of a cylindrical diffuser located inside an endotracheal tube, was fixed in a tank filled with dilute 0.01% intralipid. Light dosimetry was performed around the tip of the wand using two complementary methods: direct measurements of light power with an isotropic probe and measurements of light distribution characterization.
Dosimetry with the isotropic probe showed an ellipse-shaped illumination. An optimized effective attenuation coefficient was deduced. Combined with the spatial representation, a theoretical illumination profile was established with iso-surfaces of fluence rate, defining a gradient light dose according to the distance from the diffuser.
A theoretical illumination profile of a light device was established and could be part of an intra-operative dosimetry system to improve light delivery during intrapleural PDT.
胸腔的完全且均匀照明对于间皮瘤光动力疗法（PDT）的成功至关重要，但仍然是一项挑战。了解光在光施加器周围的分布和传播可能是优化剂量测定的第一步。在此，我们提出一种特定光设备照明轮廓的表征方法。
由位于气管内导管内的圆柱形扩散器制成的光棒固定在装有0.01%稀释脂质乳剂的水箱中。使用两种互补方法在光棒尖端周围进行光剂量测定：用各向同性探头直接测量光功率以及测量光分布特征。
用各向同性探头进行的剂量测定显示出椭圆形照明。推导出了优化的有效衰减系数。结合空间表示，根据通量率的等值面建立了理论照明轮廓，根据与扩散器的距离定义了梯度光剂量。
建立了一种光设备的理论照明轮廓，其可成为术中剂量测定系统的一部分，以改善胸膜内光动力疗法期间的光传递。
