Sule Sangeeta, Fontaine Kevin
Department of Pediatrics, Johns Hopkins University, 200 N. Wolfe Street, Suite 2126, Baltimore, MD, 21287, USA.
University of Alabama at Birmingham School of Public Health, 1720 2nd Avenue South, RPHB 214C, Birmingham, AL, 35294, USA.
Pediatr Rheumatol Online J. 2016 Sep 5;14(1):50. doi: 10.1186/s12969-016-0110-8.
Children with SLE are known to have higher fat mass compared to their peers but there are no published data regarding exercise capacity as measured by cardiovascular endurance and muscle strength. In our pilot study of ten children with SLE, we sought to examine body composition, cardiovascular endurance, and isometric muscle strength.
Ten pediatric SLE patients were studied with a mean age of 15.5 years and 90 % female. Percent body fat above 30 %, the recommended normal level in adolescent females, were found in 89 % of female subjects and 40 % of all participants had lower than the recommended norms of muscle mass for their age/gender. Subjects with renal disease were more likely to have low muscle mass compared to those without renal disease (p = 0.03). Cardiovascular endurance was reported as estimated maximal oxygen consumption (VO2max) during cycle ergometry. All participants scored in less than fifth percentile for VO2max measurements compared to data from age and gender matched published norms. Isokinetic muscle strength testing was performed on upper and lower extremities. Only one participant (male subject) reached goal percentiles for age and gender.
We found significant deficit in body composition, muscle strength and cardiovascular endurance in the pediatric SLE population compared to reported published norms. Clinicians should consider these data and focus on exercise programs that can increase aerobic capacity and muscle strength in this high-risk population.
已知与同龄人相比，系统性红斑狼疮（SLE）患儿的脂肪量更高，但尚无关于通过心血管耐力和肌肉力量来衡量运动能力的公开数据。在我们对10名SLE患儿的初步研究中，我们试图研究身体成分、心血管耐力和等长肌肉力量。
对10名儿科SLE患者进行了研究，平均年龄为15.5岁，90%为女性。在89%的女性受试者中发现体脂百分比高于青少年女性推荐的正常水平，40%的所有参与者的肌肉量低于其年龄/性别的推荐标准。与无肾脏疾病的患者相比，患有肾脏疾病的患者更有可能肌肉量较低（p = 0.03）。心血管耐力通过在自行车测力计测试期间的估计最大耗氧量（VO2max）来报告。与年龄和性别匹配的已发表标准数据相比，所有参与者的VO2max测量得分均低于第五百分位数。对等速肌肉力量进行了上下肢测试。只有一名参与者（男性受试者）达到了年龄和性别的目标百分位数。
与已发表的标准相比，我们发现儿科SLE人群在身体成分、肌肉力量和心血管耐力方面存在显著不足。临床医生应考虑这些数据，并关注能够提高这一高危人群有氧能力和肌肉力量的运动项目。
