Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet Huddinge, Sweden.
Scand J Rheumatol. 2012 Aug;41(4):290-7. doi: 10.3109/03009742.2011.624117. Epub 2012 May 31.
As physical activity reduces cardiovascular disease (CVD) in the general population, studies concerning the frequency of physical activity in patients with systemic lupus erythematosus (SLE) are needed. Earlier studies indicate that patients with SLE are physically inactive but there are few studies that compare physical activity in SLE to that in the general population. The aim of this study was to examine different aspects of physical activity in patients with SLE and population controls and to investigate how they relate to disease activity and organ damage.
Two hundred and seventy-two patients with SLE and 272 population controls, individually matched for age, gender, and living region, were investigated clinically. For patients, the investigation included assessment of disease activity using the SLE Disease Activity Index (SLEDAI) and organ damage using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC) Damage Index. All participants filled out an extensive questionnaire concerning physical activity, exercise capacity, and sedentary behaviour.
The mean age of the patients was 47 (SD 15) years. Patients reported lower (p < 0.001) capacity for walking, jogging, and running and more limiting factors for these activities than controls (p < 0.001). Patients exercised less often than controls (p < 0.01) and patients with SLICC ≥ 2 points reported less physical activity on 'low to moderate' intensity compared to their controls (p < 0.05). Sedentary behaviour was reported by 18% of the patients and 26% of the controls (ns).
Patients with SLE reported lower exercise capacity and less frequent exercise than controls. Additionally, patients with more organ damage reported less physical activity, and these, together with patients who have a sedentary behaviour, should be the focus of intervention programmes to support increased physical activity and exercise in SLE.
体力活动可降低普通人群的心血管疾病（CVD）风险，因此有必要研究系统性红斑狼疮（SLE）患者的体力活动频率。早期研究表明，SLE 患者体力活动不足，但比较 SLE 患者与普通人群体力活动的研究较少。本研究旨在调查 SLE 患者和人群对照者体力活动的不同方面，并探讨其与疾病活动和器官损害的关系。
对 272 例 SLE 患者和 272 名年龄、性别和居住地区相匹配的人群对照者进行临床调查。对患者进行 SLE 疾病活动指数（SLEDAI）评估疾病活动，采用系统性红斑狼疮国际合作临床中心/美国风湿病学会（SLICC）损害指数评估器官损害。所有参与者均填写了一份关于体力活动、运动能力和久坐行为的详细问卷。
患者的平均年龄为 47（SD 15）岁。与对照组相比，患者报告的步行、慢跑和跑步能力较低（p < 0.001），且存在更多限制这些活动的因素（p < 0.001）。患者锻炼频率低于对照组（p < 0.01），SLICC≥2 分的患者报告“低至中度”强度的体力活动较对照组少（p < 0.05）。18%的患者和 26%的对照组报告有久坐行为（无统计学差异）。
SLE 患者报告的运动能力较低，锻炼频率也较低。此外，器官损害较多的患者报告体力活动较少，这些患者和有久坐行为的患者应成为干预计划的重点，以支持 SLE 患者增加体力活动和锻炼。
