Chobanian A V, Lichtenstein A H, Nilakhe V, Haudenschild C C, Drago R, Nickerson C
Cardiovascular Institute, Boston University School of Medicine, 02118.
Hypertension. 1989 Aug;14(2):203-9. doi: 10.1161/01.hyp.14.2.203.
The effects of one-kidney, one clip Goldblatt hypertension on aortic atherosclerosis have been studied in the Watanabe heritable hyperlipidemic (WHHL) rabbit. Renovascular surgery was performed on WHHL rabbits at 3 months of age, and the rabbits were followed for periods of 3-6 months. Aortic atherosclerosis was assessed by measurement of intimal surface involvement with atherosclerotic lesions, determination of aortic free and ester cholesterol content, and microscopic examination. Systolic blood pressure increased by approximately 40-60 mm Hg in the renovascular surgical group as compared with the sham-operated group, but body weight, heart rate, serum cholesterol, and serum triglyceride were unaffected. Aortic atherosclerosis was increased in the hypertensive rabbits, even after 2-3 months of hypertension. At 3 months after renovascular surgery, the aortic surface area covered by atherosclerotic disease averaged 77 +/- 4.4% in hypertensive as compared with 16 +/- 3.3 in control rabbits. At 6 months after surgery, the values were 62 +/- 8.2% and 30 +/- 5.3% in the hypertensive and control rabbits, respectively. The differences in surface involvement and cholesterol content as a result of hypertension were particularly prominent in the descending thoracic aorta. Atherosclerotic lesions in the descending thoracic and abdominal aortic regions of normotensive WHHL rabbits were localized primarily to the ostia of branch vessels, but in the hypertensive rabbits, the involvement was typically very diffuse. No major differences in the nature of atherosclerotic lesions of comparable size were apparent by light microscopy. The results indicate that hypertension accelerates atherogenesis in the WHHL rabbit and suggest that this model may be valuable for studying the mechanisms by which such acceleration is induced.
在渡边遗传性高脂血症（WHHL）兔中研究了单肾单夹型戈德布拉特高血压对主动脉动脉粥样硬化的影响。对3月龄的WHHL兔进行肾血管手术，并对这些兔进行3 - 6个月的随访。通过测量动脉粥样硬化病变累及的内膜表面、测定主动脉游离胆固醇和酯胆固醇含量以及显微镜检查来评估主动脉动脉粥样硬化。与假手术组相比，肾血管手术组的收缩压升高了约40 - 60 mmHg，但体重、心率、血清胆固醇和血清甘油三酯未受影响。即使在高血压2 - 3个月后，高血压兔的主动脉动脉粥样硬化仍有所加重。肾血管手术后3个月，高血压兔中被动脉粥样硬化疾病覆盖的主动脉表面积平均为77±4.4%，而对照兔为16±3.3%。手术后6个月，高血压兔和对照兔的相应数值分别为62±8.2%和30±5.3%。高血压导致的表面累及和胆固醇含量差异在胸降主动脉尤为显著。正常血压的WHHL兔胸降主动脉和腹主动脉区域的动脉粥样硬化病变主要局限于分支血管开口处，但在高血压兔中，累及通常非常广泛。通过光学显微镜观察，大小相当的动脉粥样硬化病变的性质没有明显的主要差异。结果表明，高血压加速了WHHL兔的动脉粥样硬化形成，并提示该模型对于研究这种加速形成的机制可能具有重要价值。
