Martin P J
Int J Parasitol. 1989 May;19(3):317-25. doi: 10.1016/0020-7519(89)90143-4.
Thiabendazole (TBZ) treatment of grazing weaners infected with a predominantly susceptible strain of Ostertagia reduced worm burdens by 90%. The surviving sub population had a level of resistance four times greater than the original population when compared to similarly infected, but untreated, weaners. TBZ treated and control weaners were relocated to worm-free pasture so that the contamination on the plots grazed by TBZ treated weaners was from the survivors of the drench. The anthelmintic treated groups were subsequently managed under a two summer drench programme while control groups remained so throughout the experiment. Monitoring both parasite population size and the degree of resistance over the following 2 years indicated that after three anthelmintic treatments, resistance developed to a level where TBZ was ineffective. When compared to control groups, a mean reduction in population size of around 80% was maintained in the TBZ treated groups for 1 year. This difference, however, disappeared by the second year. A similar study over 1 year with a moderately TBZ resistant strain of Ostertagia indicated that TBZ treatment produced no significant reduction in population size but more than doubled the level of resistance. The study indicated the critical need for highly efficient anthelmintic treatment, particularly in situations where, through ecology or management, post treatment contamination is likely to contribute substantially to future generations of worms.
用噻苯达唑（TBZ）治疗感染了主要为易感奥斯特他线虫菌株的放牧断奶仔猪，可使蠕虫负荷降低90%。与同样感染但未治疗的断奶仔猪相比，存活的亚群体的抗性水平比原始群体高四倍。将经TBZ治疗的断奶仔猪和对照断奶仔猪转移到无蠕虫的牧场，以便经TBZ治疗的断奶仔猪放牧地块上的污染来自驱虫后的幸存者。随后，驱虫治疗组按照两年夏季驱虫方案进行管理，而对照组在整个实验过程中保持不变。在接下来的两年中监测寄生虫种群大小和抗性程度，结果表明，经过三次驱虫治疗后，抗性发展到TBZ无效的水平。与对照组相比，经TBZ治疗的组在1年内种群大小平均减少约80%。然而，这种差异在第二年消失。另一项针对对TBZ具有中度抗性的奥斯特他线虫菌株进行的为期1年的类似研究表明，TBZ治疗并未使种群大小显著减少，但抗性水平增加了一倍多。该研究表明迫切需要高效的驱虫治疗，特别是在通过生态学或管理方式，治疗后污染可能对后代蠕虫有重大影响的情况下。
