Zhao Jinshan, Li Hegang, Liu Kaidong, Zhang Baoxun, Li Peipei, He Jianning, Cheng Ming, De Wei, Liu Jifeng, Zhao Yaofeng, Yang Lihua, Liu Nan
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong 266109, P.R. China.
Department of Reproduction and Breeding, Qingdao Institute of Animal Science and Veterinary Medicine, Qingdao, Shandong 266100, P.R. China.
Mol Med Rep. 2016 Oct;14(4):3823-31. doi: 10.3892/mmr.2016.5728. Epub 2016 Sep 6.
Goats are an important source of fibers. In the present study microarray technology was used to investigate the potential genes primarily involved in hair and cashmere growth in the Laiwu black goat. A total of 655 genes differentially expressed in body (hair‑growing) and groin (hairless) skin were identified, and their potential association with hair and cashmere growth was analyzed. The majority of genes associated with hair growth regulation could be assigned to intracellular, intracellular organelle, membrane‑bound vesicle, cytoplasmic vesicle, pattern binding, heparin binding, polysaccharide binding, glycosaminoglycan binding and cytoplasmic membrane‑bound vesicle categories. Numerous genes upregulated in body compared with groin skin contained common motifs for nuclear factor 1A, Yi, E2 factor (E2F) and cyclic adenosine monophosphate response element binding (CREB)/CREBβ binding sites in their promoter region. The promoter region of certain genes downregulated in body compared with groin skin contained three common regions with LF‑A1, Yi, E2F, Collier/Olfactory‑1/early B‑cell factor 1, peroxisome proliferator‑activated receptor α or U sites. Thus, the present study identified molecules in the cashmere‑bearing skin area of the Laiwu black goat, which may contribute to hair and cashmere traits.
山羊是纤维的重要来源。在本研究中，利用微阵列技术研究了莱芜黑山羊中主要参与毛发和羊绒生长的潜在基因。共鉴定出655个在体部（有毛）和腹股沟（无毛）皮肤中差异表达的基因，并分析了它们与毛发和羊绒生长的潜在关联。大多数与毛发生长调控相关的基因可归类为细胞内、细胞内细胞器、膜结合囊泡、细胞质囊泡、模式结合、肝素结合、多糖结合、糖胺聚糖结合和细胞质膜结合囊泡类别。与腹股沟皮肤相比，体部上调的众多基因在其启动子区域含有核因子1A、Yi、E2因子（E2F）和环磷酸腺苷反应元件结合（CREB）/CREBβ结合位点的共同基序。与腹股沟皮肤相比，体部下调的某些基因的启动子区域含有与LF‑A1、Yi、E2F、Collier/Olfactory‑1/early B‑cell factor 1、过氧化物酶体增殖物激活受体α或U位点的三个共同区域。因此，本研究在莱芜黑山羊的产绒皮肤区域鉴定出了一些分子，这些分子可能影响毛发和羊绒的性状。
