Ding Qiang, Lu Panpan, Ding Shuping, Fan Yuhui, Yan Wei, Wang Ying, Tian Dean, Xia Yujia, Liu Mei
Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Medicine (Baltimore). 2016 Sep;95(36):e4685. doi: 10.1097/MD.0000000000004685.
Ménétrier disease (MD) is rare that is involved in both the small bowel and entire colon.
We describe a case of a 76-year-old male patient whose clinical presentations include intermittent diarrhea, epigastric pain, nausea, vomiting, asitia, and weight loss. An endoscopy was performed showing a large number of irregular forms and different sizes of polypoid lesions in the gastrointestinal tract, which is rare for MD.
THE MAIN DIAGNOSES, THERAPEUTICS INTERVENTIONS, AND OUTCOMES: Herein, this case was diagnosed as MD, mainly dependent on endoscopic evaluation, typical clinical symptoms, and histopathological examination of biopsy. As this patient was also infected with Helicobacter pylori, the eradication of H pylori was administered. Meanwhile, a high-protein diet was enjoined, the aforementioned patient's symptoms were alleviated evidently after 1 month.
Although the etiology of MD remained undetermined, we showed that eradication of H pylori in this case might contribute to the disease remission. This study enlarged the present understanding of MD.
胃黏膜巨肥厚症(MD)罕见,累及小肠和全结肠。
我们描述了一例76岁男性患者,其临床表现包括间歇性腹泻、上腹部疼痛、恶心、呕吐、腹水和体重减轻。进行了内镜检查,显示胃肠道有大量形态不规则、大小各异的息肉样病变,这在MD中较为罕见。
主要诊断、治疗干预及结果:在此,该病例被诊断为MD,主要依据内镜评估、典型临床症状及活检的组织病理学检查。由于该患者还感染了幽门螺杆菌,遂进行了幽门螺杆菌根除治疗。同时,嘱咐患者采用高蛋白饮食,1个月后上述患者症状明显缓解。
尽管MD的病因仍未明确,但我们发现该病例中根除幽门螺杆菌可能有助于疾病缓解。本研究拓展了对MD的现有认识。