• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

沙利度胺诱导术后克罗恩病内镜复发的黏膜愈合：病例报告及文献综述

Thalidomide induces mucosal healing in postoperative Crohn disease endoscopic recurrence: Case report and literature review.

作者信息

Hu Huiqin, Wang Xinying, Liu Side

机构信息

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

出版信息

Medicine (Baltimore). 2016 Sep;95(36):e4799. doi: 10.1097/MD.0000000000004799.

DOI:10.1097/MD.0000000000004799
PMID:27603389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5023912/
Abstract

BACKGROUND

Thalidomide has been successful use in patients with refractory Crohn disease (CD) in recent years.

METHODS

We collected the data of a postoperative CD patient who was prescribed thalidomide to induce remission and reviewed the relevant literatures.

RESULTS

A 51-year-old female was diagnosed as CD after an urgent terminal intestinal resection and presented endoscopic recurrence despite the prophylactic treatment with azathioprine (AZA). Fortunately, she achieved mucosal healing (MH) at a low dose of thalidomide for 15 months.

CONCLUSION

Thalidomide is effective to induce MH in the postoperative CD endoscopic recurrence.

摘要

背景

近年来，沙利度胺已成功应用于难治性克罗恩病（CD）患者。

方法

我们收集了一名术后CD患者的数据，该患者服用沙利度胺以诱导缓解，并查阅了相关文献。

结果

一名51岁女性在紧急末端肠切除术后被诊断为CD，尽管使用硫唑嘌呤（AZA）进行了预防性治疗，但仍出现内镜复发。幸运的是，她在低剂量沙利度胺治疗15个月后实现了黏膜愈合（MH）。

结论

沙利度胺可有效诱导术后CD内镜复发患者实现黏膜愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acf1/5023912/15361638690e/medi-95-e4799-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acf1/5023912/47e50c58b2ad/medi-95-e4799-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acf1/5023912/47cccc7914ee/medi-95-e4799-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acf1/5023912/15361638690e/medi-95-e4799-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acf1/5023912/47e50c58b2ad/medi-95-e4799-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acf1/5023912/47cccc7914ee/medi-95-e4799-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acf1/5023912/15361638690e/medi-95-e4799-g003.jpg

相似文献

1
Thalidomide induces mucosal healing in postoperative Crohn disease endoscopic recurrence: Case report and literature review.沙利度胺诱导术后克罗恩病内镜复发的黏膜愈合：病例报告及文献综述
Medicine (Baltimore). 2016 Sep;95(36):e4799. doi: 10.1097/MD.0000000000004799.
2
Mucosal healing with thalidomide in refractory Crohn's disease patients intolerant of anti-TNF-α drugs: report of 3 cases and literature review.沙利度胺用于不耐受抗TNF-α药物的难治性克罗恩病患者的黏膜愈合：3例报告及文献综述
J Clin Gastroenterol. 2014 Jul;48(6):530-3. doi: 10.1097/MCG.0000000000000122.
3
Systematic versus Endoscopy-driven Treatment with Azathioprine to Prevent Postoperative Ileal Crohn's Disease Recurrence.硫唑嘌呤系统性治疗与内镜引导治疗预防术后回肠克罗恩病复发的比较
J Crohns Colitis. 2015 Aug;9(8):617-24. doi: 10.1093/ecco-jcc/jjv076. Epub 2015 Apr 29.
4
Thalidomide as treatment of crohn-like disease occurred after allogeneic hematopoietic stem cell transplantation in a pediatric patient.沙利度胺治疗异基因造血干细胞移植后儿童发生的类克罗恩病。
Pediatr Transplant. 2021 May;25(3):e13941. doi: 10.1111/petr.13941. Epub 2020 Dec 12.
5
Endoscopic and Histologic Healing in Children With Inflammatory Bowel Diseases Treated With Thalidomide.沙利度胺治疗儿童炎症性肠病的内镜和组织学愈合。
Clin Gastroenterol Hepatol. 2017 Sep;15(9):1382-1389.e1. doi: 10.1016/j.cgh.2017.02.029. Epub 2017 Mar 7.
6
A prospective 52 week mucosal healing assessment of small bowel Crohn's disease as detected by capsule endoscopy.通过胶囊内镜检测对小肠克罗恩病进行为期52周的前瞻性黏膜愈合评估。
J Crohns Colitis. 2014 Dec;8(12):1601-9. doi: 10.1016/j.crohns.2014.09.005. Epub 2014 Sep 23.
7
Efficacy of long-term treatment with thalidomide in children and young adults with Crohn disease: preliminary results.沙利度胺长期治疗儿童及年轻成人克罗恩病的疗效：初步结果
J Pediatr Gastroenterol Nutr. 2001 Feb;32(2):178-81. doi: 10.1097/00005176-200102000-00016.
8
Thalidomide-induced sinus bradycardia in Crohn's disease: case report and literature review.沙利度胺诱发克罗恩病患者窦性心动过缓：病例报告及文献综述
J Int Med Res. 2019 May;47(5):2228-2233. doi: 10.1177/0300060519833293. Epub 2019 Mar 5.
9
Impact of azathioprine on the prevention of postoperative Crohn's disease recurrence: results of a prospective, observational, long-term follow-up study.硫唑嘌呤对预防克罗恩病术后复发的影响：一项前瞻性、观察性、长期随访研究的结果
Inflamm Bowel Dis. 2008 Apr;14(4):508-13. doi: 10.1002/ibd.20359.
10
Endoscopic Recurrence 6 Months After Ileocecal Resection in Children With Crohn Disease Treated With Azathioprine.接受硫唑嘌呤治疗的克罗恩病患儿回盲部切除术后6个月的内镜复发情况
J Pediatr Gastroenterol Nutr. 2017 Aug;65(2):207-211. doi: 10.1097/MPG.0000000000001470.

引用本文的文献

1
Identification of four key biomarkers and small molecule drugs in nasopharyngeal carcinoma by weighted gene co-expression network analysis.基于加权基因共表达网络分析鉴定鼻咽癌的四个关键生物标志物和小分子药物。
Bioengineered. 2021 Dec;12(1):3647-3661. doi: 10.1080/21655979.2021.1949844.
2
Thalidomide Prevented and Ameliorated Pathogenesis of Crohn's Disease in Mice Regulation of Inflammatory Response and Fibrosis.沙利度胺预防并改善小鼠克罗恩病的发病机制：炎症反应和纤维化的调节
Front Pharmacol. 2019 Dec 13;10:1486. doi: 10.3389/fphar.2019.01486. eCollection 2019.
3
Thalidomide-induced sinus bradycardia in Crohn's disease: case report and literature review.

本文引用的文献

1
Long-term Outcomes of Thalidomide Therapy for Adults With Refractory Crohn's Disease.沙利度胺治疗成人难治性克罗恩病的长期疗效。
Clin Gastroenterol Hepatol. 2016 Jul;14(7):966-972.e2. doi: 10.1016/j.cgh.2015.10.034. Epub 2015 Nov 18.
2
Thalidomide Treatment of Pediatric Ulcerative Colitis: A New Use for an Old Drug.沙利度胺治疗小儿溃疡性结肠炎：一种旧药的新用途。
Inflamm Bowel Dis. 2015 Aug;21(8):1750-1. doi: 10.1097/MIB.0000000000000430.
3
Surgical recurrence in Crohn's disease: Are we getting better?克罗恩病的手术复发：我们是否在取得进展？
沙利度胺诱发克罗恩病患者窦性心动过缓：病例报告及文献综述
J Int Med Res. 2019 May;47(5):2228-2233. doi: 10.1177/0300060519833293. Epub 2019 Mar 5.
World J Gastroenterol. 2015 May 28;21(20):6097-100. doi: 10.3748/wjg.v21.i20.6097.
4
Systematic review: thalidomide and thalidomide analogues for treatment of inflammatory bowel disease.系统评价：沙利度胺和沙利度胺类似物治疗炎症性肠病。
Aliment Pharmacol Ther. 2015 Jun;41(11):1079-93. doi: 10.1111/apt.13181. Epub 2015 Apr 8.
5
Editorial: is thalidomide a good option for patients with refractory Crohn's disease?社论：沙利度胺对难治性克罗恩病患者是一个好的选择吗？
Aliment Pharmacol Ther. 2015 Apr;41(8):785-6. doi: 10.1111/apt.13106.
6
Long-term outcomes of thalidomide in refractory Crohn's disease.沙利度胺治疗难治性克罗恩病的长期疗效。
Aliment Pharmacol Ther. 2015 Mar;41(5):429-37. doi: 10.1111/apt.13057. Epub 2014 Dec 15.
7
Prevention and treatment of postoperative Crohn's disease recurrence with anti-TNF therapy: a meta-analysis of controlled trials.抗TNF治疗预防和治疗克罗恩病术后复发：对照试验的荟萃分析
Dig Liver Dis. 2015 Mar;47(3):191-6. doi: 10.1016/j.dld.2014.11.005. Epub 2014 Nov 14.
8
Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease.欧洲克罗恩病和结肠炎组织/欧洲儿科胃肠病、肝病和营养学会关于儿童克罗恩病药物治疗的共识指南。
J Crohns Colitis. 2014 Oct;8(10):1179-207. doi: 10.1016/j.crohns.2014.04.005. Epub 2014 Jun 6.
9
Thalidomide and refractory Crohn's disease: what is in the future?沙利度胺与难治性克罗恩病：未来何去何从？
J Clin Gastroenterol. 2014 Jul;48(6):476-7. doi: 10.1097/MCG.0000000000000136.
10
Mucosal healing with thalidomide in refractory Crohn's disease patients intolerant of anti-TNF-α drugs: report of 3 cases and literature review.沙利度胺用于不耐受抗TNF-α药物的难治性克罗恩病患者的黏膜愈合：3例报告及文献综述
J Clin Gastroenterol. 2014 Jul;48(6):530-3. doi: 10.1097/MCG.0000000000000122.