作为单纯疱疹病毒 1 型和 2 型病毒进入抑制剂的 GAG 模拟功能化固体和介孔硅纳米粒子。
GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses.
机构信息
The University of Queensland, School of Pharmacy, Brisbane, QLD 4072, Australia.
出版信息
Nanoscale. 2016 Sep 28;8(36):16192-6. doi: 10.1039/c6nr03878f. Epub 2016 Sep 7.
PMID:27604476
Abstract
A glycosaminoglycan mimetic was attached to the surface of solid and mesoporous silica nanoparticles to create novel antiviral agents against herpes simplex type 1 and type 2 viruses. The nanoparticles act as viral entry inhibitors that appear to block viral attachment and penetration into susceptible cells.
摘要
一种糖胺聚糖模拟物被连接到固体和介孔硅纳米粒子的表面，以创建针对单纯疱疹病毒 1 型和 2 型的新型抗病毒药物。这些纳米粒子作为病毒进入抑制剂，似乎可以阻止病毒附着和侵入易感细胞。
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