系统生物学在脑损伤生物标志物发现中的作用：神经蛋白质组学应用

Role of Systems Biology in Brain Injury Biomarker Discovery: Neuroproteomics Application.

作者信息

Jaber Zaynab, Aouad Patrick, Al Medawar Mohamad, Bahmad Hisham, Abou-Abbass Hussein, Ghandour Hiba, Mondello Stefania, Kobeissy Firas

机构信息

Department of Biochemistry, Graduate School and University Center of CUNY, 365 Fifth Avenue, New York, NY, 10016, USA.

Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

出版信息

Methods Mol Biol. 2016;1462:157-74. doi: 10.1007/978-1-4939-3816-2_10.

DOI:10.1007/978-1-4939-3816-2_10

PMID:27604718

Abstract

Years of research in the field of neurotrauma have led to the concept of applying systems biology as a tool for biomarker discovery in traumatic brain injury (TBI). Biomarkers may lead to understanding mechanisms of injury and recovery in TBI and can be potential targets for wound healing, recovery, and increased survival with enhanced quality of life. The literature available on neurotrauma studies from both animal and clinical studies has provided rich insight on the molecular pathways and complex networks of TBI, elucidating the proteomics of this disease for the discovery of biomarkers. With such a plethora of information available, the data from the studies require databases with tools to analyze and infer new patterns and associations. The role of different systems biology tools and their use in biomarker discovery in TBI are discussed in this chapter.

摘要

神经创伤领域多年的研究催生了将系统生物学作为创伤性脑损伤（TBI）生物标志物发现工具的概念。生物标志物可能有助于理解TBI的损伤和恢复机制，并且可能成为伤口愈合、恢复以及提高生存率和改善生活质量的潜在靶点。来自动物和临床研究的神经创伤研究文献，为TBI的分子途径和复杂网络提供了丰富的见解，阐明了该疾病的蛋白质组学以用于生物标志物的发现。有了如此大量可用的信息，研究数据需要具备分析和推断新模式及关联的工具的数据库。本章将讨论不同系统生物学工具的作用及其在TBI生物标志物发现中的应用。