肾钙质沉着症的遗传学、病理生理学及临床方面
Genetic, pathophysiological, and clinical aspects of nephrocalcinosis.
作者信息
Oliveira Ben, Kleta Robert, Bockenhauer Detlef, Walsh Stephen B
机构信息
University College London, Centre for Nephrology, London, United Kingdom.
University College London, Centre for Nephrology, London, United Kingdom
出版信息
Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1243-F1252. doi: 10.1152/ajprenal.00211.2016. Epub 2016 Sep 7.
Nephrocalcinosis describes the ectopic deposition of calcium salts in the kidney parenchyma. Nephrocalcinosis can result from a number of acquired causes but also an even greater number of genetic diseases, predominantly renal but also extrarenal. Here we provide a review of the genetic causes of nephrocalcinosis, along with putative mechanisms, illustrated by human and animal data.
肾钙质沉着症是指钙盐在肾实质中的异位沉积。肾钙质沉着症可由多种后天性病因引起，但也可由更多的遗传性疾病导致，主要是肾脏疾病，但也有肾外疾病。在此，我们结合人类和动物数据所阐明的假定机制，对肾钙质沉着症的遗传病因进行综述。
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