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髓质肾钙质沉着症与原发性醛固酮增多症——一种罕见且认识不足的关联。

Medullary nephrocalcinois and primary hyperaldosteronism - A rare and under recognised association.

机构信息

Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India.

出版信息

J Postgrad Med. 2024 Jul 1;70(3):166-168. doi: 10.4103/jpgm.jpgm_296_24. Epub 2024 Aug 12.

Abstract

Medullary nephrocalcinosis is an uncommon manifestation of primary hyperaldosteronism (PHA) and the exact etiology of this association is still debated. Here we report three cases of PHA with medullary nephrocalcinosis and how medullary nephrocalcinosis in one patient led to misdiagnosis as renal tubular acidosis (RTA). Although PHA and RTA can share overlapping symptoms, careful evaluation of clinical presentation, biochemical tests, and imaging studies are essential to differentiate between the two conditions and ensure appropriate management. Also, awareness of this uncommon manifestation of PHA is essential to avoid misdiagnosis as tubulopathy, as this may delay the treatment.

摘要

髓质肾钙质沉着症是原发性醛固酮增多症(PHA)的一种罕见表现,其确切病因仍存在争议。本文报告了 3 例 PHA 合并髓质肾钙质沉着症的病例,以及其中 1 例髓质肾钙质沉着症导致误诊为肾小管酸中毒(RTA)的情况。尽管 PHA 和 RTA 可能有重叠的症状,但仔细评估临床表现、生化检查和影像学研究对于区分这两种疾病并确保适当的治疗至关重要。此外,了解 PHA 这种不常见的表现对于避免误诊为肾小管病至关重要,因为这可能会延误治疗。

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本文引用的文献

1
Nephrocalcinosis-A gateway to the Diagnosis.肾钙质沉着症——诊断的切入点
Indian J Nephrol. 2021 Nov-Dec;31(6):562-565. doi: 10.4103/ijn.IJN_397_19. Epub 2021 Nov 9.
3
Nephrocalcinosis: A Diagnostic Conundrum.肾钙质沉着症:一个诊断难题。
Am J Kidney Dis. 2018 Apr;71(4):A12-A14. doi: 10.1053/j.ajkd.2017.11.025.
4
Genetic, pathophysiological, and clinical aspects of nephrocalcinosis.肾钙质沉着症的遗传学、病理生理学及临床方面
Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1243-F1252. doi: 10.1152/ajprenal.00211.2016. Epub 2016 Sep 7.
7
Management of hypertension in primary aldosteronism.原发性醛固酮增多症的高血压管理
World J Cardiol. 2014 May 26;6(5):227-33. doi: 10.4330/wjc.v6.i5.227.

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