Bag S, Behari M, Ahuja G K, Karmarkar M G
Department of Neurology, All India Institute of Medical Sciences, New Delhi.
J Neurol. 1989 Jul;236(5):311-3. doi: 10.1007/BF00314466.
In a prospective study, 30 pregnant epileptic patients were followed through their pregnancy to determine the effect of seizures on pregnancy and its outcome and the effect of pregnancy on seizures. An attempt was made to correlate the serum hormone and anticonvulsant drug levels with seizure frequency, complications of pregnancy, occurrence of status epilepticus and teratogenicity. In 14 patients seizure frequency increased, in 15 it remained unchanged and in 1 patient it decreased. There were 2 spontaneous abortions, 2 patients had status epilepticus and 1 offspring of a patient had a ventricular septal defect. This patient was receiving carbamazepine and diphenylhydantoin. Patients with increased seizures frequency had significantly higher oestrogen levels, lower level of progesterone and lower level of anticonvulsant drugs as compared with those with no change in seizures. Patients who had abortions and those who developed status epilepticus had high serum oestrogen levels.
在一项前瞻性研究中，对30名妊娠癫痫患者进行了全程跟踪，以确定癫痫发作对妊娠及其结局的影响以及妊娠对癫痫发作的影响。研究试图将血清激素和抗惊厥药物水平与癫痫发作频率、妊娠并发症、癫痫持续状态的发生情况以及致畸性联系起来。14名患者的癫痫发作频率增加，15名患者的发作频率保持不变，1名患者的发作频率降低。有2例自然流产，2例患者发生癫痫持续状态，1例患者的子代患有室间隔缺损。该患者正在服用卡马西平和苯妥英钠。与癫痫发作频率无变化的患者相比，癫痫发作频率增加的患者雌激素水平显著更高，孕酮水平和抗惊厥药物水平更低。发生流产的患者和发生癫痫持续状态的患者血清雌激素水平较高。
