Moon Su-Young, Proussaloglou Emmanuel, Peterson Gregory W, DeCoste Jared B, Hall Morgan G, Howarth Ashlee J, Hupp Joseph T, Farha Omar K
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA.
Edgewood Chemical Biological Center, US Army Research, Development, and Engineering Command, 5183 Blackhawk Road, Aberdeen Proving Ground, MD, 21010, USA.
Chemistry. 2016 Oct 10;22(42):14864-14868. doi: 10.1002/chem.201603976. Epub 2016 Sep 8.
Owing to their high surface area, periodic distribution of metal sites, and water stability, zirconium-based metal-organic frameworks (Zr -MOFs) have shown promising activity for the hydrolysis of nerve agents GD and VX, as well as the simulant, dimethyl 4-nitrophenylphosphate (DMNP), in buffered solutions. A hurdle to using MOFs for this application is the current need for a buffer solution. Here the destruction of the simulant DMNP, as well as the chemical warfare agents (GD and VX) through hydrolysis using a MOF catalyst mixed with a non-volatile, water-insoluble, heterogeneous buffer is reported. The hydrolysis of the simulant and nerve agents in the presence of the heterogeneous buffer was fast and effective.
由于具有高表面积、金属位点的周期性分布以及水稳定性，锆基金属有机框架材料（Zr-MOFs）在缓冲溶液中对神经毒剂GD和VX以及模拟剂4-硝基苯基磷酸二甲酯（DMNP）的水解表现出了良好的活性。将MOFs用于此应用的一个障碍是目前需要缓冲溶液。本文报道了使用与非挥发性、水不溶性多相缓冲剂混合的MOF催化剂通过水解来破坏模拟剂DMNP以及化学战剂（GD和VX）。在多相缓冲剂存在下，模拟剂和神经毒剂的水解快速且有效。
