Martelli Fabrizio, Binzoni Tiziano, Sekar Sanathana Konugolu Venkata, Farina Andrea, Cavalieri Stefano, Pifferi Antonio
Opt Express. 2016 Sep 5;24(18):20382-99. doi: 10.1364/OE.24.020382.
A set of time-domain analytical forward solvers for Raman signals detected from homogeneous diffusive media is presented. The time-domain solvers have been developed for two geometries: the parallelepiped and the finite cylinder. The potential presence of a background fluorescence emission, contaminating the Raman signal, has also been taken into account. All the solvers have been obtained as solutions of the time dependent diffusion equation. The validation of the solvers has been performed by means of comparisons with the results of "gold standard" Monte Carlo simulations. These forward solvers provide an accurate tool to explore the information content encoded in the time-resolved Raman measurements.
本文提出了一组用于从均匀扩散介质中检测到的拉曼信号的时域解析正向求解器。时域求解器针对两种几何形状开发：平行六面体和有限圆柱体。还考虑了可能存在的背景荧光发射对拉曼信号的污染。所有求解器均作为时间相关扩散方程的解获得。通过与“金标准”蒙特卡罗模拟结果进行比较，对求解器进行了验证。这些正向求解器为探索时间分辨拉曼测量中编码的信息内容提供了一个准确的工具。
