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[腹腔念珠菌病的诊断与治疗方法]

[Diagnostic and therapeutic approach of intraabdominal candidiasis].

作者信息

Montero A, Gilsanz F, Maseda E

机构信息

Emilio Maseda, Servicio de Anestesia y Reanimación, Hospital Universitario La Paz, Paseo de la Castellana 261; 28046, Madrid, Spain.

出版信息

Rev Esp Quimioter. 2016 Sep;29 Suppl 1:52-5.

Abstract

Invasive fungal disease is associated to a high mortality rate on critical ill patients. In the last decades an important epidemiological shift has been described. Early diagnosis and treatment are related with a better prognosis. The key factors lie in a set of predictive scores that allow to identify patients that will benefit of early treatment, as well as using diagnosis techniques that are culture independent. New diagnosis approximations are being developed with promising results: in situ hybridisation using PNA-FISH probes, MALDI-TOF MS and rapid nucleic acids detection assays. The use of echinocandin is recommended as antifungal therapy on critical ill patients with candida peritonitis.

摘要

侵袭性真菌病与危重症患者的高死亡率相关。在过去几十年中,已描述了重要的流行病学转变。早期诊断和治疗与较好的预后相关。关键因素在于一组预测评分,其可用于识别将从早期治疗中获益的患者,以及使用不依赖培养的诊断技术。正在开发具有良好前景的新诊断方法:使用肽核酸荧光原位杂交(PNA-FISH)探针的原位杂交、基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)和快速核酸检测测定法。对于患有念珠菌性腹膜炎的危重症患者,推荐使用棘白菌素作为抗真菌治疗。

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