Sustar A, Nikolac Perkovic M, Nedic Erjavec G, Svob Strac D, Pivac N
Clinics for Treatment, Rehabilitation and Prevention of Cardiovascular Diseases, University Hospital Thalassotherapia, Opatija, Croatia; Referral Center of the Ministry of Health for Rehabilitation of the Patients with Coronary Heart Disease, Opatija, Croatia; and School of Medicine, University of Rijeka, Rijeka, Croatia.
Eur Rev Med Pharmacol Sci. 2016 Aug;20(16):3417-26.
Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor with an important role in the regulation of body weight, body mass index (BMI) and obesity. Increased BMI that leads to obesity is a substantial risk factor for coronary heart disease (CHD). The functional BDNF Val66Met polymorphism (rs6265) has been associated with CHD, obesity and BMI. The aim of the study was to determine the association between BDNF rs6265 polymorphism and CHD and/or BMI in patients with CHD and healthy control subjects.
The study included 704 Caucasian subjects: 206 subjects with CHD and 498 healthy control subjects. The BDNF rs6265 genotype frequency was similar in male and female subjects, and there were no differences in the frequency of the BDNF rs6265 genotypes in 206 patients with CHD and in 498 healthy subjects. When study participants were subdivided according to the BMI categories into normal weight, overweight and obese subjects, significantly different BDNF rs6265 genotype frequency was found within healthy subjects, but not within patients with CHD. Healthy subjects, but not patients with CHD, subdivided into carriers of the Met/Met, Met/Val and Val/Val genotype, had different BMI scores.
The BDNF rs6265 genotype frequency was similar in male and female subjects, and there were no differences in the frequency of the BDNF rs6265 genotypes in 206 patients with CHD and in 498 healthy subjects. When study participants were subdivided according to the BMI categories into normal weight, overweight and obese subjects, significantly different BDNF rs6265 genotype frequency was found within healthy subjects, but not within patients with CHD. Healthy subjects, but not patients with CHD, subdivided into carriers of the Met/Met, Met/Val and Val/Val genotype, had different BMI scores. BDNF rs6265 polymorphism was not associated with a diagnosis of CHD or with BMI categories among patients with CHD. In contrast, healthy Caucasians, carriers of the BDNF Met/Met genotype, had more frequently normal weight compared to carriers of other BDNF genotypesBDNF rs6265 polymorphism was not associated with a diagnosis of CHD or with BMI categories among patients with CHD. In contrast, healthy Caucasians, carriers of the BDNF Met/Met genotype, had more frequently normal weight compared to carriers of other BDNF genotypes.
BDNF rs6265 polymorphism is associated with BMI categories, and the BDNF Met/Met genotype has a protective role in obesity in healthy subjects, while this effect was not present in patients with CHD.
脑源性神经营养因子（BDNF）是一种神经营养因子，在体重、体重指数（BMI）及肥胖症的调节中发挥重要作用。导致肥胖症的BMI升高是冠心病（CHD）的一个重要危险因素。功能性BDNF Val66Met多态性（rs6265）与冠心病、肥胖症及BMI相关。本研究旨在确定BDNF rs6265多态性与冠心病患者及健康对照者的冠心病和/或BMI之间的关联。
本研究纳入704名白种人受试者：206名冠心病患者和498名健康对照者。BDNF rs6265基因型频率在男性和女性受试者中相似，在206例冠心病患者和498名健康受试者中，BDNF rs6265基因型频率无差异。当根据BMI类别将研究参与者分为正常体重、超重和肥胖受试者时，在健康受试者中发现BDNF rs6265基因型频率存在显著差异，但在冠心病患者中未发现。分为Met/Met、Met/Val和Val/Val基因型携带者的健康受试者，而非冠心病患者，具有不同的BMI评分。
BDNF rs6265基因型频率在男性和女性受试者中相似，在206例冠心病患者和498名健康受试者中，BDNF rs6265基因型频率无差异。当根据BMI类别将研究参与者分为正常体重、超重和肥胖受试者时，在健康受试者中发现BDNF rs6265基因型频率存在显著差异，但在冠心病患者中未发现。分为Met/Met、Met/Val和Val/Val基因型携带者的健康受试者，而非冠心病患者，具有不同的BMI评分。BDNF rs6265多态性与冠心病的诊断或冠心病患者的BMI类别无关。相比之下，与其他BDNF基因型携带者相比，BDNF Met/Met基因型携带者的健康白种人正常体重更为常见。BDNF rs6265多态性与冠心病的诊断或冠心病患者的BMI类别无关。相比之下，与其他BDNF基因型携带者相比，BDNF Met/Met基因型携带者的健康白种人正常体重更为常见。
BDNF rs6265多态性与BMI类别相关，BDNF Met/Met基因型对健康受试者的肥胖症具有保护作用，而在冠心病患者中不存在这种效应。
