Goldfield Gary S, Walsh Jeremy, Sigal Ronald J, Kenny Glen P, Hadjiyannakis Stasia, De Lisio Michael, Ngu Mathew, Prud'homme Denis, Alberga Angela S, Doucette Steve, Goldfield Diana B, Cameron Jameason D
Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
Front Neurosci. 2021 Nov 12;15:715330. doi: 10.3389/fnins.2021.715330. eCollection 2021.
The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is functionally related to BDNF, and is associated with obesity and metabolic complications in adults, but limited research exists among adolescents. This study comparatively examined carriers and non-carriers of the BDNF Val66Met polymorphism on body composition, energy intake, and cardiometabolic profile among adolescents with obesity. The sample consisted of 187 adolescents with obesity; 99 were carriers of the homozygous Val (G/G) alleles and 88 were carriers of the Val/Met (G/A) or Met (A/A) alleles. Cardiometabolic profile and DNA were quantified from fasted blood samples. Body composition was assessed by magnetic resonance imaging (MRI). Compared to carriers of the homozygous Val (G/G) allele, carriers of the Val/Met (G/A) or Met/Met (A/A) variants exhibited significantly higher protein ( = 0.01) and fat ( = 0.05) intake, C-Reactive protein ( = 0.05), and a trend toward higher overall energy intake ( = 0.07), fat-free mass ( = 0.07), and lower HDL-C ( = 0.07) Results showed for the first time that among youth with obesity, carriers of the Val66Met BDNF Met-alleles exhibited significantly higher C-reactive protein and energy intake in the form of fat and protein compared to Val-allele carriers, thereby providing support for the possible role of BDNF in appetite, weight, and metabolic regulation during adolescence. http://clinicaltrials.gov/, identifier NCT00195858.
脑源性神经营养因子（BDNF）Val66Met多态性在功能上与BDNF相关，并且与成年人的肥胖和代谢并发症有关，但在青少年中的研究有限。本研究比较了肥胖青少年中BDNF Val66Met多态性的携带者和非携带者在身体成分、能量摄入和心脏代谢状况方面的差异。样本包括187名肥胖青少年；99名是纯合Val（G/G）等位基因的携带者，88名是Val/Met（G/A）或Met（A/A）等位基因的携带者。从空腹血样中定量分析心脏代谢状况和DNA。通过磁共振成像（MRI）评估身体成分。与纯合Val（G/G）等位基因的携带者相比，Val/Met（G/A）或Met/Met（A/A）变体的携带者表现出显著更高的蛋白质摄入量（P = 0.01）和脂肪摄入量（P = 0.05）、C反应蛋白（P = 0.05），并且有总体能量摄入量更高的趋势（P = 0.07）、去脂体重更高的趋势（P = 0.07）以及高密度脂蛋白胆固醇更低的趋势（P = 0.07）。结果首次表明，在肥胖青少年中，与Val等位基因携带者相比，BDNF Met等位基因的携带者表现出显著更高的C反应蛋白以及以脂肪和蛋白质形式存在的能量摄入量，从而为BDNF在青少年食欲、体重和代谢调节中的可能作用提供了支持。 （临床试验注册网址：http://clinicaltrials.gov/，标识符：NCT00195858）
