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难治性格雷夫斯眼眶病的内侧及内外侧眼眶减压术

Medial and mediolateral orbital decompression in intractable Graves' Orbitopathy.

作者信息

Seibel Ira, Hofmann Veit Maria, Sönmez Hasibe, Schönfeld Shideh, Jumah Masen Dirk, Lenarz Minoo, Coordes Annekatrin

机构信息

Department of Ophthalmology, Charité, University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany.

Department of Otorhinolaryngology, Head and Neck Surgery, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany.

出版信息

Auris Nasus Larynx. 2017 Aug;44(4):428-434. doi: 10.1016/j.anl.2016.08.007. Epub 2016 Sep 5.

Abstract

OBJECTIVE

Graves' Orbitopathy (GO) has well established treatment guidelines; however, its management is still controversial. The aim was to evaluate the results of medial and mediolateral orbital decompression (OD) in intractable GO.

METHODS

Retrospective chart review of all patients with advanced stages of GO, who underwent medial (1-wall) or mediolateral (2-wall) OD between May 2012 and November 2014 in our institution. Ophthalmologic examinations included visual acuity, Hertel exophthalmometry (proptosis), intraocular pressure (IOP), visual field (30:2) and diplopia. Follow-up was performed 1 week, 3 months and 1 year postoperatively. Additionally, a questionnaire was used to investigate subjective benefits.

RESULTS

The study included 34 eyes of 20 patients. In our study, GO patients who underwent mediolateral OD had significantly higher IOP preoperatively (p<0.05) and lower visual acuity, proptosis and visual field compared with patients who underwent medial OD. After 1- and 2-wall OD, visual acuity, proptosis, visual field and IOP in upgaze improved significantly. Using a questionnaire, the patients reported significant improvements in impaired vision, eye pain and pressure, vitality and social life. 94% of all patients reported they would repeat the operation. After 2-wall OD, the surgical scar had little effect.

CONCLUSION

With GO patients in advanced stages, both medial (1-wall) and mediolateral (2-wall) OD procedures are convincing therapeutic options. In more advanced GO stages with high IOP, 2-wall OD should be prioritized, as mediolateral OD had superior long-term functional outcomes.

摘要

目的

格雷夫斯眼眶病(GO)已有完善的治疗指南;然而,其治疗仍存在争议。本研究旨在评估内侧及内外侧眼眶减压术(OD)治疗难治性GO的效果。

方法

回顾性分析2012年5月至2014年11月在我院接受内侧(单壁)或内外侧(双壁)OD的所有晚期GO患者的病历。眼科检查包括视力、赫特尔眼球突出计测量(眼球突出度)、眼压(IOP)、视野(30:2)和复视情况。术后1周、3个月和1年进行随访。此外,使用问卷调查来调查主观获益情况。

结果

本研究纳入20例患者的34只眼。在我们的研究中,接受内外侧OD的GO患者术前IOP显著更高(p<0.05),与接受内侧OD的患者相比,视力、眼球突出度和视野更低。单壁和双壁OD术后,上视时的视力、眼球突出度、视野和IOP均有显著改善。通过问卷调查,患者报告视力受损、眼痛和眼压、活力及社交生活方面有显著改善。94%的患者表示他们愿意再次接受手术。双壁OD术后,手术瘢痕影响较小。

结论

对于晚期GO患者,内侧(单壁)和内外侧(双壁)OD手术都是令人信服的治疗选择。在IOP较高的更晚期GO阶段,应优先选择双壁OD,因为内外侧OD具有更好的长期功能预后。

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