Collins B J, Van Loon F P, Molla A, Molla A M, Alam N H
International Centre for Diarrhoeal Diseases Research, Bangladesh.
J Trop Med Hyg. 1989 Aug;92(4):290-4.
Gastric emptying of rice powder electrolyte solution and of glucose electrolyte solution was measured by a marker dilution double sampling technique in 14 and in 16 adult patients respectively after intravenous rehydration during an attack of acute cholera. Six patients who received rice powder electrolyte solution and seven who received glucose electrolyte solution re-attended for a repeat study with the same test meal 16 days later, when fully recovered from cholera. No differences in gastric emptying patterns of the two electrolyte solutions were observed, either in the acute or in the recovered patients. Similarly, gastric emptying of both solutions was rapid during acute cholera and comparable to that observed in recovered patients. This study indicates that gastric emptying is not impaired in acute cholera and that the rate of emptying of oral rehydration solutions is adequate to account for their observed clinical efficacy in fast purging patients with acute cholera.
在急性霍乱发作期间静脉补液后，分别采用标记稀释双样本技术对14例和16例成年患者的米粉电解质溶液和葡萄糖电解质溶液的胃排空情况进行了测量。6例接受米粉电解质溶液的患者和7例接受葡萄糖电解质溶液的患者在霍乱完全康复16天后再次前来，用相同的试验餐进行重复研究。无论是在急性期还是康复期患者中，均未观察到两种电解质溶液胃排空模式的差异。同样，在急性霍乱期间，两种溶液的胃排空都很快，且与康复患者中观察到的情况相当。这项研究表明，急性霍乱时胃排空未受损，口服补液溶液的排空速率足以解释其在急性霍乱快速清除患者中观察到的临床疗效。
