摇头丸中药物杂质的影响：气相色谱-质谱研究
Impact of Pharmaceutical Impurities in Ecstasy Tablets: Gas Chromatography-Mass Spectrometry Study.
作者信息
Jalali Amir, Hatamie Amir, Saferpour Tahere, Khajeamiri Alireza, Safa Tahere, Buazar Foad
机构信息
Dept of Pharmacology and Toxicology, Faculty of Pharmacy and Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Dept of Chemistry, Faculty of Sciences, Shahid Chamran Universitry of Ahvaz, Ahvaz, Iran.
出版信息
Iran J Pharm Res. 2016 Winter;15(1):221-9.
In this study, a simple and reliable method by gas chromatograph-mass spectrometry (GC-MS) was developed for the fast and regular identification of 3, 4-MDMA impurities in ecstasy tablets. In so doing, 8 samples of impurities were extracted by diethyl ether under alkaline condition and then analyzed by GC-MS. The results revealed high MDMA levels ranging from 37.6% to 57.7%. The GC-MS method showed that unambiguous identification can be achieved for MDMA from 3, 4-methylenedioxyamphetamine (MDA), Amphetamine (AM), methamphetamine (MA) and ketamine (Keta) compounds, respectively. The experimental results indicated the acceptable time window without interfering peaks. It is found that GC-MS was provided a suitable and rapid identification approach for MDMA (Ecstacy) tablets, particularly in the Forensic labs. Consequently, the intense MDMA levels would support the police to develop a simple quantification of impurity in Ecstasy tablets.
在本研究中，开发了一种简单可靠的气相色谱 - 质谱联用（GC - MS）方法，用于快速、常规地鉴定摇头丸片中的3,4 - 亚甲基二氧甲基苯丙胺（MDMA）杂质。为此，在碱性条件下用乙醚提取了8个杂质样品，然后进行GC - MS分析。结果显示MDMA含量较高，范围为37.6%至57.7%。GC - MS方法表明，分别可以从3,4 - 亚甲基二氧苯丙胺（MDA）、苯丙胺（AM）、甲基苯丙胺（MA）和氯胺酮（Keta）化合物中明确鉴定出MDMA。实验结果表明了无干扰峰的可接受时间窗口。结果发现，GC - MS为摇头丸片提供了一种合适且快速的鉴定方法，特别是在法医实验室。因此，高含量的MDMA水平将有助于警方开发一种简单的摇头丸片杂质定量方法。
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