麻醉大鼠肾神经对中枢压力反射的调节

Central baroreflex regulation by the renal nerves in anesthetized rats.

作者信息

Takeda K, Nakamura Y, Itoh H, Hirata M, Nakata T, Kawasaki S, Hayashi J, Oguro M, Sasaki S, Nakagawa M

机构信息

Second Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.

出版信息

Jpn Circ J. 1989 Apr;53(4):329-35. doi: 10.1253/jcj.53.329.

DOI:10.1253/jcj.53.329

PMID:2761074

Abstract

To determine whether the renal nerves affect central baroreflex regulation, the aortic depressor nerve (ADN) was stimulated electrically, while blood pressure, heart rate, and splanchnic nerve activity were recorded in renal denervated and sham-operated rats anesthetized with urethane. Tail cuff systolic pressure fell 6 days after renal denervation, but mean blood pressure recorded after anesthetizing with urethane did not differ between renal denervated and sham-operated rats. Urinary sodium excretion was greater in renal denervated than in sham-operated rats. ADN stimulation produced frequency-dependent falls in blood pressure accompanied by inhibitions of sympathetic nerve activity and heart rate. Depressor and sympathetic inhibitory responses to ADN stimulation were significantly smaller in renal denervated than in sham-operated rats. These findings suggest that the renal nerves can regulate baroreflexes centrally.

摘要

为了确定肾神经是否影响中枢压力反射调节，在用乌拉坦麻醉的去肾神经大鼠和假手术大鼠中，电刺激主动脉减压神经（ADN），同时记录血压、心率和内脏神经活动。去肾神经6天后尾袖收缩压下降，但用乌拉坦麻醉后记录的平均血压在去肾神经大鼠和假手术大鼠之间没有差异。去肾神经大鼠的尿钠排泄量比假手术大鼠多。ADN刺激使血压随频率下降，同时伴有交感神经活动和心率的抑制。去肾神经大鼠对ADN刺激的降压和交感抑制反应明显小于假手术大鼠。这些发现表明肾神经可以在中枢调节压力反射。